Heart Failure End Points in Cardiovascular Outcome Trials of Sodium Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes Mellitus: A Critical Evaluation of Clinical and Regulatory Issues.

Journal Article (Journal Article;Review)

Following regulatory guidance set forth in 2008 by the US Food and Drug Administration for new drugs for type 2 diabetes mellitus, many large randomized, controlled trials have been conducted with the primary goal of assessing the safety of antihyperglycemic medications on the primary end point of major adverse cardiovascular events, defined as cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke. Heart failure (HF) was not specifically mentioned in the US Food and Drug Administration guidance and therefore it was not a focus of these studies when planned. Several trials subsequently showed the impact of antihyperglycemic drugs on HF outcomes, which were not originally specified as the primary end point of the trials. The most impressive finding has been the substantial and consistent risk reduction in HF hospitalization seen across 4 trials of sodium glucose cotransporter 2 inhibitors. However, to date, these results have not led to regulatory approval of any of these drugs for a HF indication or a recommendation for use by US HF guidelines. It is therefore important to explore to what extent persuasive treatment effects on nonprimary end points can be used to support regulatory claims and guideline recommendations. This topic was discussed by researchers, clinicians, industry sponsors, regulators, and representatives from professional societies, who convened on the US Food and Drug Administration campus on March 6, 2019. This report summarizes these discussions and the key takeaway messages from this meeting.

Full Text

Duke Authors

Cited Authors

  • Butler, J; Packer, M; Greene, SJ; Fiuzat, M; Anker, SD; Anstrom, KJ; Carson, PE; Cooper, LB; Fonarow, GC; Hernandez, AF; Januzzi, JL; Jessup, M; Kalyani, RR; Kaul, S; Kosiborod, M; Lindenfeld, J; McGuire, DK; Sabatine, MS; Solomon, SD; Teerlink, JR; Vaduganathan, M; Yancy, CW; Stockbridge, N; O'Connor, CM

Published Date

  • December 17, 2019

Published In

Volume / Issue

  • 140 / 25

Start / End Page

  • 2108 - 2118

PubMed ID

  • 31841369

Pubmed Central ID

  • PMC7027964

Electronic International Standard Serial Number (EISSN)

  • 1524-4539

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.119.042155


  • eng

Conference Location

  • United States