Essential Ingredients and Innovations in the Design and Analysis of Group-Randomized Trials.


Journal Article

This article reviews the essential ingredients and innovations in the design and analysis of group-randomized trials. The methods literature for these trials has grown steadily since they were introduced to the biomedical research community in the late 1970s, and we summarize those developments. We review, in addition to the group-randomized trial, methods for two closely related designs, the individually randomized group treatment trial and the stepped-wedge group-randomized trial. After describing the essential ingredients for these designs, we review the most important developments in the evolution of their methods using a new bibliometric tool developed at the National Institutes of Health. We then discuss the questions to be considered when selecting from among these designs or selecting the traditional randomized controlled trial. We close with a review of current methods for the analysis of data from these designs, a case study to illustrate each design, and a brief summary.

Full Text

Duke Authors

Cited Authors

  • Murray, DM; Taljaard, M; Turner, EL; George, SM

Published Date

  • April 2, 2020

Published In

Volume / Issue

  • 41 /

Start / End Page

  • 1 - 19

PubMed ID

  • 31869281

Pubmed Central ID

  • 31869281

Electronic International Standard Serial Number (EISSN)

  • 1545-2093

Digital Object Identifier (DOI)

  • 10.1146/annurev-publhealth-040119-094027


  • eng

Conference Location

  • United States