Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents.
Published
Journal Article
Autoimmune diseases are chronic inflammatory diseases associated with high morbidity and mortality. Treatment options for autoimmune diseases have increased over the past several decades, but they are, in general, limited in their clinical efficacy due to high toxicity and lack of selectivity. Thus, efforts must be made to identify new immunomodulatory agents that are effective through a novel mechanism to circumvent existing side effects. To define the structural requirements of subglutinols for immunomodulatory activity and to provide guiding principles on future therapeutic development, we prepared and evaluated several subglutinol analogs for their immunomodulatory activities. Our efforts identified a subglutinol analog with reduced structural complexity as a potential lead compound for future autoimmune drug development. Our study will provide an important framework for the design of potent and nontoxic immunomodulating agents derived from subglutinols.
Full Text
Duke Authors
Cited Authors
- Park, H; Christian, LS; Kim, MJ; Li, Q-J; Hong, J
Published Date
- January 9, 2020
Published In
Volume / Issue
- 63 / 1
Start / End Page
- 283 - 294
PubMed ID
- 31793781
Pubmed Central ID
- 31793781
Electronic International Standard Serial Number (EISSN)
- 1520-4804
Digital Object Identifier (DOI)
- 10.1021/acs.jmedchem.9b01579
Language
- eng
Conference Location
- United States