The Complexity of Conducting a Multicenter Clinical Trial: Taking It to the Next Level Stipulated by the Federal Agencies.
Randomized controlled trials are becoming increasingly difficult to organize and conduct efficiently. This, in turn, hinders the ability to derive the highest level of evidence. Often, investigators forget or remain unaware of essential practices that will help them fulfill their study goals. This article emphasizes the common issues that a study team experiences during the planning and conducting of randomized controlled trials. The authors sought to share remedies to overcome these issues with the experience garnered in conducting several multicenter clinical trials and observational studies. In addition, the authors list resources from sponsors such as the National Institutes of Health and the U.S. Food and Drug Administration that study teams can apply to undertake studies effectively.
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Related Subject Headings
- United States Government Agencies
- United States
- Surgery
- Sample Size
- Research Personnel
- Randomized Controlled Trials as Topic
- Pilot Projects
- Patient Selection
- National Institutes of Health (U.S.)
- Multicenter Studies as Topic
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- United States Government Agencies
- United States
- Surgery
- Sample Size
- Research Personnel
- Randomized Controlled Trials as Topic
- Pilot Projects
- Patient Selection
- National Institutes of Health (U.S.)
- Multicenter Studies as Topic