Hardware Design and Experimental Demonstrations for Digital Acoustofluidic Biochips

Conference Paper

A digital microfluidic biochip (DMB) is an attractive platform for automating laboratory procedures in microbiology. To overcome the problem of cross-contamination due to fouling of the electrode surface in traditional DMBs, a contactless liquid-handling biochip technology, referred to as acoustofluidics, has recently been proposed. A major challenge in operating this platform is the need for a control signal of frequency 24 MHz and voltage range ±10/ ±20 V to activate the inter-digital-Transducer (IDT) units in the biochip. A preliminary solution based on amplifiers, mechanical relays, and jump wires introduces signal loss (at least 6dB), signal coupling, and waveform distortion. In this paper, we present a new IDT-driver design that offers three major advantages: smaller form factor and lower cost, effective and high-quality signal generation and transmission, and fully-Automated and flexible biochip control. Experimental demonstrations of droplet routing and a simple bioassay highlight the effectiveness of our hardware design.

Full Text

Duke Authors

Cited Authors

  • Zhong, Z; Zhu, H; Zhang, P; Morizio, J; Huang, TJ; Chakrabarty, K

Published Date

  • October 1, 2019

Published In

  • Biocas 2019 Biomedical Circuits and Systems Conference, Proceedings

International Standard Book Number 13 (ISBN-13)

  • 9781509006175

Digital Object Identifier (DOI)

  • 10.1109/BIOCAS.2019.8919148

Citation Source

  • Scopus