Bivalent peptides as PDZ domain ligands.
Publication
, Journal Article
Klosi, E; Saro, D; Spaller, MR
Published in: Bioorganic & medicinal chemistry letters
November 2007
A series of multivalent peptides, with the ability to simultaneously bind two separate PDZ domain proteins, has been designed, synthesized, and tested by isothermal titration calorimetry (ITC). The monomer sequences, linked with succinate, varied in length from five to nine residues. The thermodynamic binding parameters, in conjunction with results from mass spectrometry, indicate that a ternary complex is formed in which each peptide arm binds two equivalents of the third PDZ domain (PDZ3) of the neuronal protein PSD-95.
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Published In
Bioorganic & medicinal chemistry letters
DOI
EISSN
1464-3405
ISSN
0960-894X
Publication Date
November 2007
Volume
17
Issue
22
Start / End Page
6147 / 6150
Related Subject Headings
- Thermodynamics
- Protein Binding
- Peptides
- PDZ Domains
- Molecular Sequence Data
- Medicinal & Biomolecular Chemistry
- Ligands
- Amino Acid Sequence
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Klosi, E., Saro, D., & Spaller, M. R. (2007). Bivalent peptides as PDZ domain ligands. Bioorganic & Medicinal Chemistry Letters, 17(22), 6147–6150. https://doi.org/10.1016/j.bmcl.2007.09.035
Klosi, Edvin, Dorina Saro, and Mark R. Spaller. “Bivalent peptides as PDZ domain ligands.” Bioorganic & Medicinal Chemistry Letters 17, no. 22 (November 2007): 6147–50. https://doi.org/10.1016/j.bmcl.2007.09.035.
Klosi E, Saro D, Spaller MR. Bivalent peptides as PDZ domain ligands. Bioorganic & medicinal chemistry letters. 2007 Nov;17(22):6147–50.
Klosi, Edvin, et al. “Bivalent peptides as PDZ domain ligands.” Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 22, Nov. 2007, pp. 6147–50. Epmc, doi:10.1016/j.bmcl.2007.09.035.
Klosi E, Saro D, Spaller MR. Bivalent peptides as PDZ domain ligands. Bioorganic & medicinal chemistry letters. 2007 Nov;17(22):6147–6150.
Published In
Bioorganic & medicinal chemistry letters
DOI
EISSN
1464-3405
ISSN
0960-894X
Publication Date
November 2007
Volume
17
Issue
22
Start / End Page
6147 / 6150
Related Subject Headings
- Thermodynamics
- Protein Binding
- Peptides
- PDZ Domains
- Molecular Sequence Data
- Medicinal & Biomolecular Chemistry
- Ligands
- Amino Acid Sequence
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry