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Bivalent peptides as PDZ domain ligands.

Publication ,  Journal Article
Klosi, E; Saro, D; Spaller, MR
Published in: Bioorganic & medicinal chemistry letters
November 2007

A series of multivalent peptides, with the ability to simultaneously bind two separate PDZ domain proteins, has been designed, synthesized, and tested by isothermal titration calorimetry (ITC). The monomer sequences, linked with succinate, varied in length from five to nine residues. The thermodynamic binding parameters, in conjunction with results from mass spectrometry, indicate that a ternary complex is formed in which each peptide arm binds two equivalents of the third PDZ domain (PDZ3) of the neuronal protein PSD-95.

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Published In

Bioorganic & medicinal chemistry letters

DOI

EISSN

1464-3405

ISSN

0960-894X

Publication Date

November 2007

Volume

17

Issue

22

Start / End Page

6147 / 6150

Related Subject Headings

  • Thermodynamics
  • Protein Binding
  • Peptides
  • PDZ Domains
  • Molecular Sequence Data
  • Medicinal & Biomolecular Chemistry
  • Ligands
  • Amino Acid Sequence
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
 

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Klosi, E., Saro, D., & Spaller, M. R. (2007). Bivalent peptides as PDZ domain ligands. Bioorganic & Medicinal Chemistry Letters, 17(22), 6147–6150. https://doi.org/10.1016/j.bmcl.2007.09.035
Klosi, Edvin, Dorina Saro, and Mark R. Spaller. “Bivalent peptides as PDZ domain ligands.Bioorganic & Medicinal Chemistry Letters 17, no. 22 (November 2007): 6147–50. https://doi.org/10.1016/j.bmcl.2007.09.035.
Klosi E, Saro D, Spaller MR. Bivalent peptides as PDZ domain ligands. Bioorganic & medicinal chemistry letters. 2007 Nov;17(22):6147–50.
Klosi, Edvin, et al. “Bivalent peptides as PDZ domain ligands.Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 22, Nov. 2007, pp. 6147–50. Epmc, doi:10.1016/j.bmcl.2007.09.035.
Klosi E, Saro D, Spaller MR. Bivalent peptides as PDZ domain ligands. Bioorganic & medicinal chemistry letters. 2007 Nov;17(22):6147–6150.
Journal cover image

Published In

Bioorganic & medicinal chemistry letters

DOI

EISSN

1464-3405

ISSN

0960-894X

Publication Date

November 2007

Volume

17

Issue

22

Start / End Page

6147 / 6150

Related Subject Headings

  • Thermodynamics
  • Protein Binding
  • Peptides
  • PDZ Domains
  • Molecular Sequence Data
  • Medicinal & Biomolecular Chemistry
  • Ligands
  • Amino Acid Sequence
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry