Bivalent peptides as PDZ domain ligands.

Journal Article (Journal Article)

A series of multivalent peptides, with the ability to simultaneously bind two separate PDZ domain proteins, has been designed, synthesized, and tested by isothermal titration calorimetry (ITC). The monomer sequences, linked with succinate, varied in length from five to nine residues. The thermodynamic binding parameters, in conjunction with results from mass spectrometry, indicate that a ternary complex is formed in which each peptide arm binds two equivalents of the third PDZ domain (PDZ3) of the neuronal protein PSD-95.

Full Text

Duke Authors

Cited Authors

  • Klosi, E; Saro, D; Spaller, MR

Published Date

  • November 2007

Published In

Volume / Issue

  • 17 / 22

Start / End Page

  • 6147 - 6150

PubMed ID

  • 17890086

Pubmed Central ID

  • PMC2169291

Electronic International Standard Serial Number (EISSN)

  • 1464-3405

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2007.09.035


  • eng