Bivalent peptides as PDZ domain ligands.
Journal Article
A series of multivalent peptides, with the ability to simultaneously bind two separate PDZ domain proteins, has been designed, synthesized, and tested by isothermal titration calorimetry (ITC). The monomer sequences, linked with succinate, varied in length from five to nine residues. The thermodynamic binding parameters, in conjunction with results from mass spectrometry, indicate that a ternary complex is formed in which each peptide arm binds two equivalents of the third PDZ domain (PDZ3) of the neuronal protein PSD-95.
Full Text
Duke Authors
Cited Authors
- Klosi, E; Saro, D; Spaller, MR
Published Date
- November 2007
Published In
Volume / Issue
- 17 / 22
Start / End Page
- 6147 - 6150
PubMed ID
- 17890086
Pubmed Central ID
- 17890086
Electronic International Standard Serial Number (EISSN)
- 1464-3405
International Standard Serial Number (ISSN)
- 0960-894X
Digital Object Identifier (DOI)
- 10.1016/j.bmcl.2007.09.035
Language
- eng