The interplay between structure-based design and combinatorial chemistry.
The two most lauded drug design approaches from the past century--structure-based design and combinatorial chemistry--are increasingly experiencing integration, whereby the three-dimensional coordinates of a receptor supports the development of combinatorial-based ligand design. A selective polling of the recent literature demonstrates that this can be actualized in many ways.
Rupasinghe, CN; Spaller, MR
Volume / Issue
Start / End Page
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)