The interplay between structure-based design and combinatorial chemistry.

Journal Article (Review;Journal Article)

The two most lauded drug design approaches from the past century--structure-based design and combinatorial chemistry--are increasingly experiencing integration, whereby the three-dimensional coordinates of a receptor supports the development of combinatorial-based ligand design. A selective polling of the recent literature demonstrates that this can be actualized in many ways.

Full Text

Duke Authors

Cited Authors

  • Rupasinghe, CN; Spaller, MR

Published Date

  • June 2006

Published In

Volume / Issue

  • 10 / 3

Start / End Page

  • 188 - 193

PubMed ID

  • 16616591

Electronic International Standard Serial Number (EISSN)

  • 1879-0402

International Standard Serial Number (ISSN)

  • 1367-5931

Digital Object Identifier (DOI)

  • 10.1016/j.cbpa.2006.03.014


  • eng