Synthetic strategies in combinatorial chemistry.

Journal Article (Review;Journal Article)

Different synthetic strategies are required for the two kinds of libraries being developed for combinatoral chemistry. Preparation of a 'focused' library involves conversion of a known synthetic route to the solid-phase or automated format, whereas generation of a 'prospecting' library is driven more by availability of input materials and considerations of structural novelty. While both types can be identified over the history of combinatorial chemistry, elaborating syntheses of novel, nonoligomeric, 'drug-like' molecules for use in prospecting libraries is a relatively recent development.

Full Text

Duke Authors

Cited Authors

  • Spaller, MR; Burger, MT; Fardis, M; Bartlett, PA

Published Date

  • June 1997

Published In

Volume / Issue

  • 1 / 1

Start / End Page

  • 47 - 53

PubMed ID

  • 9667834

Electronic International Standard Serial Number (EISSN)

  • 1879-0402

International Standard Serial Number (ISSN)

  • 1367-5931

Digital Object Identifier (DOI)

  • 10.1016/s1367-5931(97)80107-x


  • eng