Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation.

Journal Article (Journal Article)

Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3-8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1-8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 μg/mL and SI of 7.1.

Full Text

Duke Authors

Cited Authors

  • Yang, J-H; Wang, X-Y; Zhou, Y-P; Lu, R; Chen, C-H; Zhang, M-H; Cheng, Y-Y; Morris-Natschke, SL; Lee, K-H; Wang, Y-S

Published Date

  • December 26, 2019

Published In

Volume / Issue

  • 25 / 1

PubMed ID

  • 31888067

Pubmed Central ID

  • PMC6983056

Electronic International Standard Serial Number (EISSN)

  • 1420-3049

Digital Object Identifier (DOI)

  • 10.3390/molecules25010099

Language

  • eng

Conference Location

  • Switzerland