Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation.
Publication
, Journal Article
Yang, J-H; Wang, X-Y; Zhou, Y-P; Lu, R; Chen, C-H; Zhang, M-H; Cheng, Y-Y; Morris-Natschke, SL; Lee, K-H; Wang, Y-S
Published in: Molecules
December 26, 2019
Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3-8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1-8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 μg/mL and SI of 7.1.
Duke Scholars
Published In
Molecules
DOI
EISSN
1420-3049
Publication Date
December 26, 2019
Volume
25
Issue
1
Location
Switzerland
Related Subject Headings
- Virus Replication
- Plant Extracts
- Organic Chemistry
- Molecular Structure
- Magnetic Resonance Spectroscopy
- Humans
- HIV-1
- Clausena
- Cell Line
- Carbazoles
Citation
APA
Chicago
ICMJE
MLA
NLM
Yang, J.-H., Wang, X.-Y., Zhou, Y.-P., Lu, R., Chen, C.-H., Zhang, M.-H., … Wang, Y.-S. (2019). Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation. Molecules, 25(1). https://doi.org/10.3390/molecules25010099
Yang, Jing-Hua, Xin-Yi Wang, Yi-Ping Zhou, Rong Lu, Chin-Ho Chen, Meng-Han Zhang, Yung-Yi Cheng, Susan L. Morris-Natschke, Kuo-Hsiung Lee, and Yun-Song Wang. “Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation.” Molecules 25, no. 1 (December 26, 2019). https://doi.org/10.3390/molecules25010099.
Yang J-H, Wang X-Y, Zhou Y-P, Lu R, Chen C-H, Zhang M-H, et al. Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation. Molecules. 2019 Dec 26;25(1).
Yang, Jing-Hua, et al. “Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation.” Molecules, vol. 25, no. 1, Dec. 2019. Pubmed, doi:10.3390/molecules25010099.
Yang J-H, Wang X-Y, Zhou Y-P, Lu R, Chen C-H, Zhang M-H, Cheng Y-Y, Morris-Natschke SL, Lee K-H, Wang Y-S. Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation. Molecules. 2019 Dec 26;25(1).
Published In
Molecules
DOI
EISSN
1420-3049
Publication Date
December 26, 2019
Volume
25
Issue
1
Location
Switzerland
Related Subject Headings
- Virus Replication
- Plant Extracts
- Organic Chemistry
- Molecular Structure
- Magnetic Resonance Spectroscopy
- Humans
- HIV-1
- Clausena
- Cell Line
- Carbazoles