Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3.

Journal Article (Journal Article)

The Polymerase Chain Reaction was used to amplify ras and ras-like sequences from two human cDNA libraries. Members corresponding to each of the three major ras-subfamilies (ras, rho, and rab/YPT) were identified. The one homologous to rab/YPT, referred to here as YL8, appears to be the human homolog of the recently reported Schizosaccharomyces pombe YPT3 gene. The YL8 gene could encode a guanine nucleotide binding protein of 216 amino acids with about 70% amino acid sequence identity to S. pombe YPT3, and is transcriptionally active in a variety of human cell lines.

Full Text

Duke Authors

Cited Authors

  • Drivas, GT; Shih, A; Coutavas, EE; D'Eustachio, P; Rush, MG

Published Date

  • January 1, 1991

Published In

Volume / Issue

  • 6 / 1

Start / End Page

  • 3 - 9

PubMed ID

  • 1704119

International Standard Serial Number (ISSN)

  • 0950-9232


  • eng

Conference Location

  • England