Stressed-Out T Cells Fragment the Mind.


Journal Article

The immune system is increasingly recognized to play an integral role in regulating stress responses. In a recent article in Cell, Fan et al. demonstrate a novel mechanism through which stress drives mitochondrial fragmentation-induced xanthine accumulation in mouse CD4+ T cells, subsequently acting on oligodendrocytes to induce anxiety-like behaviors.

Full Text

Duke Authors

Cited Authors

  • Bordt, EA; Bilbo, SD

Published Date

  • January 6, 2020

Published In

PubMed ID

  • 31917111

Pubmed Central ID

  • 31917111

Electronic International Standard Serial Number (EISSN)

  • 1471-4981

International Standard Serial Number (ISSN)

  • 1471-4906

Digital Object Identifier (DOI)

  • 10.1016/


  • eng