Test Accuracy of Human Papillomavirus in Urine for Detection of Cervical Intraepithelial Neoplasia.

Journal Article (Journal Article)

The objective was to assess the diagnostic test accuracy of high-risk human papillomavirus (hrHPV) testing of self-collected urine and cervicovaginal samples for the detection of cervical intraepithelial neoplasia grade 2 or higher (CIN2+). We recruited a convenience sample of women 25 to 65 years of age who were undergoing clinically indicated colposcopy at two medical centers in North Carolina between November 2016 and January 2019. Women with normal cytology results and positive hrHPV results were also recruited. Urine samples, self-collected cervicovaginal samples, provider-collected cervical samples, and cervical biopsy samples were obtained from all enrolled women. Samples were tested for hrHPV DNA using the Onclarity assay (Becton Dickinson, Sparks, MD). Biopsy samples were histologically graded as CIN2+ or

Full Text

Duke Authors

Cited Authors

  • Rohner, E; Rahangdale, L; Sanusi, B; Knittel, AK; Vaughan, L; Chesko, K; Faherty, B; Tulenko, SE; Schmitt, JW; Romocki, LS; Sivaraman, V; Nelson, JAE; Smith, JS

Published Date

  • February 24, 2020

Published In

Volume / Issue

  • 58 / 3

PubMed ID

  • 31896666

Pubmed Central ID

  • PMC7041584

Electronic International Standard Serial Number (EISSN)

  • 1098-660X

Digital Object Identifier (DOI)

  • 10.1128/JCM.01443-19


  • eng

Conference Location

  • United States