The Enigma of CRB1 and CRB1 Retinopathies.

Journal Article (Journal Article;Review)

Mutations in the gene Crumbs homolog 1 (CRB1) are responsible for several retinopathies that are diverse in severity and phenotype. Thus, there is considerable incentive to determine how disruption of this gene causes disease. Progress on this front will aid in developing molecular diagnostics that can predict disease severity with the ultimate goal of developing therapies for CRB1 retinopathies via gene replacement. The purpose of this review is to summarize what is known regarding CRB1 and highlights information outstanding. Doing so will provide a framework toward a thorough understanding of CRB1 at the molecular and protein level with the ultimate goal of deciphering how it contributes to the disease.

Full Text

Duke Authors

Cited Authors

  • Ray, TA; Cochran, KJ; Kay, JN

Published Date

  • 2019

Published In

Volume / Issue

  • 1185 /

Start / End Page

  • 251 - 255

PubMed ID

  • 31884620

International Standard Serial Number (ISSN)

  • 0065-2598

Digital Object Identifier (DOI)

  • 10.1007/978-3-030-27378-1_41

Language

  • eng

Conference Location

  • United States