A Mini-Review of Adverse Lung Transplant Outcomes Associated With Respiratory Viruses.

Journal Article (Journal Article;Systematic Review)

Due to their overall immunocompromised state, lung transplant recipients (LTRs) are at increased risk for the development of viral respiratory infections compared to the general population. Such respiratory infections often lead to poor transplant outcomes. We performed a systematic review of the last 30 years of medical literature to summarize the impact of specific respiratory viruses on LTRs. After screening 2,150 articles for potential inclusion, 39 manuscripts were chosen for final review. We found evidence for an association of respiratory viruses including respiratory syncytial virus (RSV), parainfluenza virus, and influenza viruses with increased morbidity following transplant. Through the literature search, we also documented associations of RSV and adenovirus infections with increased mortality among LTRs. We posit that the medical literature supports aggressive surveillance for respiratory viruses among this population.

Full Text

Duke Authors

Cited Authors

  • Bailey, ES; Zemke, JN; Choi, JY; Gray, GC

Published Date

  • 2019

Published In

Volume / Issue

  • 10 /

Start / End Page

  • 2861 -

PubMed ID

  • 31921130

Pubmed Central ID

  • PMC6930876

Electronic International Standard Serial Number (EISSN)

  • 1664-3224

Digital Object Identifier (DOI)

  • 10.3389/fimmu.2019.02861


  • eng

Conference Location

  • Switzerland