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Cooperative behavior of molecular motors.

Publication ,  Journal Article
Vermeulen, KC; Stienen, GJM; Schmid, CF
Published in: Journal of muscle research and cell motility
January 2002

Both experimental evidence and theoretical models for collective effects in the working mechanism of molecular motors are reviewed at three different levels, namely: (i) interaction between the two heads of double-headed motors, particularly in processive motors like kinesin, myosin V and myosin VI, (ii) cooperative regulation of muscle thin filaments by accessory proteins and the Ca2+ level, and (iii) collective dynamic effects stemming from the mechanical coupling of molecular motors within macroscopic structures such as muscle thick filaments or axonemes. We aim to bridge the gap between structural information at the molecular level and physiological data with accompanying specific models on the one hand, and general stochastic physical models for the action of molecular motors on the other hand. An underlying assumption is that while, ultimately, the function of molecular motors will be explainable by a quantitative description of specific intramolecular dynamics and intermolecular interactions, for some coarse grained larger scale dynamic features it will be sufficient and illuminating to construct physical models that are simplified to the bare essentials.

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Published In

Journal of muscle research and cell motility

DOI

EISSN

1573-2657

ISSN

0142-4319

Publication Date

January 2002

Volume

23

Issue

1

Start / End Page

71 / 79

Related Subject Headings

  • Physiology
  • Molecular Motor Proteins
  • Models, Biological
  • Humans
  • Animals
  • 3109 Zoology
  • 3101 Biochemistry and cell biology
  • 0606 Physiology
  • 0601 Biochemistry and Cell Biology
 

Citation

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ICMJE
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Vermeulen, K. C., Stienen, G. J. M., & Schmid, C. F. (2002). Cooperative behavior of molecular motors. Journal of Muscle Research and Cell Motility, 23(1), 71–79. https://doi.org/10.1023/a:1019980613619
Vermeulen, Karen C., Ger J. M. Stienen, and Christoph F. Schmid. “Cooperative behavior of molecular motors.Journal of Muscle Research and Cell Motility 23, no. 1 (January 2002): 71–79. https://doi.org/10.1023/a:1019980613619.
Vermeulen KC, Stienen GJM, Schmid CF. Cooperative behavior of molecular motors. Journal of muscle research and cell motility. 2002 Jan;23(1):71–9.
Vermeulen, Karen C., et al. “Cooperative behavior of molecular motors.Journal of Muscle Research and Cell Motility, vol. 23, no. 1, Jan. 2002, pp. 71–79. Epmc, doi:10.1023/a:1019980613619.
Vermeulen KC, Stienen GJM, Schmid CF. Cooperative behavior of molecular motors. Journal of muscle research and cell motility. 2002 Jan;23(1):71–79.
Journal cover image

Published In

Journal of muscle research and cell motility

DOI

EISSN

1573-2657

ISSN

0142-4319

Publication Date

January 2002

Volume

23

Issue

1

Start / End Page

71 / 79

Related Subject Headings

  • Physiology
  • Molecular Motor Proteins
  • Models, Biological
  • Humans
  • Animals
  • 3109 Zoology
  • 3101 Biochemistry and cell biology
  • 0606 Physiology
  • 0601 Biochemistry and Cell Biology