Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication.
Published
Journal Article
Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial compressibility of DNA and observed the buckling of the double helix under high loads.
Full Text
Duke Authors
Cited Authors
- Goodman, RP; Schaap, IAT; Tardin, CF; Erben, CM; Berry, RM; Schmidt, CF; Turberfield, AJ
Published Date
- December 2005
Published In
Volume / Issue
- 310 / 5754
Start / End Page
- 1661 - 1665
PubMed ID
- 16339440
Pubmed Central ID
- 16339440
Electronic International Standard Serial Number (EISSN)
- 1095-9203
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.1120367
Language
- eng