Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication.
Publication
, Journal Article
Goodman, RP; Schaap, IAT; Tardin, CF; Erben, CM; Berry, RM; Schmidt, CF; Turberfield, AJ
Published in: Science (New York, N.Y.)
December 2005
Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial compressibility of DNA and observed the buckling of the double helix under high loads.
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Published In
Science (New York, N.Y.)
DOI
EISSN
1095-9203
ISSN
0036-8075
Publication Date
December 2005
Volume
310
Issue
5754
Start / End Page
1661 / 1665
Related Subject Headings
- Stereoisomerism
- Oligodeoxyribonucleotides
- Nucleic Acid Hybridization
- Nucleic Acid Conformation
- Nanotechnology
- Nanostructures
- Molecular Structure
- Models, Molecular
- Microscopy, Atomic Force
- General Science & Technology
Citation
APA
Chicago
ICMJE
MLA
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Goodman, R. P., Schaap, I. A. T., Tardin, C. F., Erben, C. M., Berry, R. M., Schmidt, C. F., & Turberfield, A. J. (2005). Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication. Science (New York, N.Y.), 310(5754), 1661–1665. https://doi.org/10.1126/science.1120367
Goodman, R. P., I. A. T. Schaap, C. F. Tardin, C. M. Erben, R. M. Berry, C. F. Schmidt, and A. J. Turberfield. “Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication.” Science (New York, N.Y.) 310, no. 5754 (December 2005): 1661–65. https://doi.org/10.1126/science.1120367.
Goodman RP, Schaap IAT, Tardin CF, Erben CM, Berry RM, Schmidt CF, et al. Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication. Science (New York, NY). 2005 Dec;310(5754):1661–5.
Goodman, R. P., et al. “Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication.” Science (New York, N.Y.), vol. 310, no. 5754, Dec. 2005, pp. 1661–65. Epmc, doi:10.1126/science.1120367.
Goodman RP, Schaap IAT, Tardin CF, Erben CM, Berry RM, Schmidt CF, Turberfield AJ. Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication. Science (New York, NY). 2005 Dec;310(5754):1661–1665.
Published In
Science (New York, N.Y.)
DOI
EISSN
1095-9203
ISSN
0036-8075
Publication Date
December 2005
Volume
310
Issue
5754
Start / End Page
1661 / 1665
Related Subject Headings
- Stereoisomerism
- Oligodeoxyribonucleotides
- Nucleic Acid Hybridization
- Nucleic Acid Conformation
- Nanotechnology
- Nanostructures
- Molecular Structure
- Models, Molecular
- Microscopy, Atomic Force
- General Science & Technology