Nonequilibrium mechanics of active cytoskeletal networks.

Journal Article (Journal Article)

Cells both actively generate and sensitively react to forces through their mechanical framework, the cytoskeleton, which is a nonequilibrium composite material including polymers and motor proteins. We measured the dynamics and mechanical properties of a simple three-component model system consisting of myosin II, actin filaments, and cross-linkers. In this system, stresses arising from motor activity controlled the cytoskeletal network mechanics, increasing stiffness by a factor of nearly 100 and qualitatively changing the viscoelastic response of the network in an adenosine triphosphate-dependent manner. We present a quantitative theoretical model connecting the large-scale properties of this active gel to molecular force generation.

Full Text

Duke Authors

Cited Authors

  • Mizuno, D; Tardin, C; Schmidt, CF; Mackintosh, FC

Published Date

  • January 1, 2007

Published In

Volume / Issue

  • 315 / 5810

Start / End Page

  • 370 - 373

PubMed ID

  • 17234946

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1134404

Language

  • eng