High-resolution probing of cellular force transmission.


Journal Article

Cells actively probe mechanical properties of their environment by exerting internally generated forces. The response they encounter profoundly affects their behavior. Here we measure in a simple geometry the forces a cell exerts suspended by two optical traps. Our assay quantifies both the overall force and the fraction of that force transmitted to the environment. Mimicking environments of varying stiffness by adjusting the strength of the traps, we found that the force transmission is highly dependent on external compliance. This suggests a calibration mechanism for cellular mechanosensing.

Full Text

Duke Authors

Cited Authors

  • Mizuno, D; Bacabac, R; Tardin, C; Head, D; Schmidt, CF

Published Date

  • April 20, 2009

Published In

Volume / Issue

  • 102 / 16

Start / End Page

  • 168102 -

PubMed ID

  • 19518758

Pubmed Central ID

  • 19518758

Electronic International Standard Serial Number (EISSN)

  • 1079-7114

International Standard Serial Number (ISSN)

  • 0031-9007

Digital Object Identifier (DOI)

  • 10.1103/physrevlett.102.168102


  • eng