Pharmacogenomics in childhood rheumatic disorders: a foundation for future individualized therapy.

Journal Article (Journal Article;Review)

Investigating the effect of genotype on drug response in children is an evolving field, with many challenges, but there is great potential to optimize safe and effective use of drugs in children. An exponential increase in available medications for use in children with rheumatic disease has opened seemingly endless genotype/phenotype relationships to explore, but challenges inherent in studying rare diseases and the often overlooked role of ontogeny contribute to limitations in pharmacogenomic studies in this population. With careful recognition of the importance of development, improved phenotyping with the incorporation of biomarkers, and expanding collaborative efforts on a national and even international scale, the field of pediatric rheumatology has the opportunity to strategically study the new therapeutic armamentarium available and provide individualized/personalized safe and effective therapies to our population of patients.

Full Text

Duke Authors

Cited Authors

  • Polk, BI; Becker, ML

Published Date

  • December 2013

Published In

Volume / Issue

  • 16 / 90

Start / End Page

  • 267 - 275

PubMed ID

  • 24333406

Electronic International Standard Serial Number (EISSN)

  • 1944-7930


  • eng

Conference Location

  • United States