Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis.

Journal Article (Journal Article)

OBJECTIVE: To investigate the involvement of neuroendocrine candidate genes in the aetiopathogenesis of juvenile idiopathic arthritis (JIA). METHODS: Single-nucleotide polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls. RESULTS: None of the polymorphisms investigated showed any statistically significant associations with JIA. CONCLUSIONS: The lack of association with polymorphisms of these neuroendocrine genes suggests that they are not involved in susceptibility to JIA.

Full Text

Duke Authors

Cited Authors

  • Donn, RP; Farhan, A; Stevans, A; Ramanan, A; Ollier, WER; Thomson, W; British Paediatric Rheumatology Study Group,

Published Date

  • August 2002

Published In

Volume / Issue

  • 41 / 8

Start / End Page

  • 930 - 936

PubMed ID

  • 12154211

Pubmed Central ID

  • 12154211

International Standard Serial Number (ISSN)

  • 1462-0324

Digital Object Identifier (DOI)

  • 10.1093/rheumatology/41.8.930

Language

  • eng

Conference Location

  • England