Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis.
Journal Article (Journal Article)
OBJECTIVE: To investigate the involvement of neuroendocrine candidate genes in the aetiopathogenesis of juvenile idiopathic arthritis (JIA). METHODS: Single-nucleotide polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls. RESULTS: None of the polymorphisms investigated showed any statistically significant associations with JIA. CONCLUSIONS: The lack of association with polymorphisms of these neuroendocrine genes suggests that they are not involved in susceptibility to JIA.
Full Text
Duke Authors
Cited Authors
- Donn, RP; Farhan, A; Stevans, A; Ramanan, A; Ollier, WER; Thomson, W; British Paediatric Rheumatology Study Group,
Published Date
- August 2002
Published In
Volume / Issue
- 41 / 8
Start / End Page
- 930 - 936
PubMed ID
- 12154211
International Standard Serial Number (ISSN)
- 1462-0324
Digital Object Identifier (DOI)
- 10.1093/rheumatology/41.8.930
Language
- eng
Conference Location
- England