Enabling Technologies for Personalized and Precision Medicine.

Journal Article (Journal Article;Review)

Individualizing patient treatment is a core objective of the medical field. Reaching this objective has been elusive owing to the complex set of factors contributing to both disease and health; many factors, from genes to proteins, remain unknown in their role in human physiology. Accurately diagnosing, monitoring, and treating disorders requires advances in biomarker discovery, the subsequent development of accurate signatures that correspond with dynamic disease states, as well as therapeutic interventions that can be continuously optimized and modulated for dose and drug selection. This work highlights key breakthroughs in the development of enabling technologies that further the goal of personalized and precision medicine, and remaining challenges that, when addressed, may forge unprecedented capabilities in realizing truly individualized patient care.

Full Text

Duke Authors

Cited Authors

  • Ho, D; Quake, SR; McCabe, ERB; Chng, WJ; Chow, EK; Ding, X; Gelb, BD; Ginsburg, GS; Hassenstab, J; Ho, C-M; Mobley, WC; Nolan, GP; Rosen, ST; Tan, P; Yen, Y; Zarrinpar, A

Published Date

  • May 2020

Published In

Volume / Issue

  • 38 / 5

Start / End Page

  • 497 - 518

PubMed ID

  • 31980301

Pubmed Central ID

  • PMC7924935

Electronic International Standard Serial Number (EISSN)

  • 1879-3096

Digital Object Identifier (DOI)

  • 10.1016/j.tibtech.2019.12.021


  • eng

Conference Location

  • England