Breast cancer brain metastases: evidence for neuronal-like adaptation in a 'breast-to-brain' transition?

Journal Article (Journal Article)

Brain metastases remain a significant challenge in the treatment of breast cancer patients due to the unique environment posed by the central nervous system. A better understanding of the biology of breast cancer cells that have metastasized to the brain is required to develop improved therapies. A recent Proceedings of the National Academy of Sciences article demonstrates that breast cancer cells in the brain microenvironment express γ-aminobutyric acid (GABA)-related genes, enabling them to utilize GABA as an oncometabolite, thus gaining a proliferative advantage. In this viewpoint, we highlight these findings and their potential impact on the treatment of breast cancer brain metastases.

Full Text

Duke Authors

Cited Authors

  • Van Swearingen, AE; Siegel, MB; Anders, CK

Published Date

  • May 2014

Published In

Volume / Issue

  • 16 / 3

Start / End Page

  • 304 -

PubMed ID

  • 25679873

Pubmed Central ID

  • PMC4052941

Electronic International Standard Serial Number (EISSN)

  • 1465-542X

International Standard Serial Number (ISSN)

  • 1465-5411

Digital Object Identifier (DOI)

  • 10.1186/bcr3651


  • eng