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IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis.

Publication ,  Journal Article
Zhang, X; Tao, Y; Chopra, M; Dujmovic-Basuroski, I; Jin, J; Tang, Y; Drulovic, J; Markovic-Plese, S
Published in: J Immunol
June 1, 2015

Clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) is the earliest clinically evident phase of the disease, which may provide valuable insight into the molecular mechanisms of the initiation of the autoimmune response in MS. Our results introduce IL-11 as a new cytokine that plays a role in the autoimmune response in the early phase of the disease. IL-11 is the highest upregulated cytokine in the sera and cerebrospinal fluid from CIS patients, which is also increased in patients with clinically definitive relapsing-remitting MS in comparison with healthy control subjects. Serum IL-11 levels are significantly increased during clinical exacerbations in comparison with remissions in the same patients. CD4(+) cells represent a predominant cell source of IL-11 in the peripheral circulation, and the percentage of IL-11(+)CD4(+) cells is significantly increased in CIS patients in comparison with healthy control subjects. Furthermore, we have identified IL-11 as a new Th17-promoting cytokine, because it induces a differentiation of naive CD4(+) T cells into Th17 cells, as well as expansion of Th17 memory cells. Because the Th17 cytokines IL-17F, IL-21 and TNF-α, and TGF-β induce differentiation of naive cells in the IL-11-secreting CD4(+) cells, we propose that cross-talk between IL-11(+)CD4(+) and Th17 cells may play a role in the inflammatory response in relapsing-remitting MS.

Duke Scholars

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Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

June 1, 2015

Volume

194

Issue

11

Start / End Page

5139 / 5149

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Transforming Growth Factor beta
  • Th17 Cells
  • Multiple Sclerosis, Relapsing-Remitting
  • Male
  • Interleukins
  • Interleukin-17
  • Interleukin-11
  • Inflammation
  • Immunology
 

Citation

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Zhang, X., Tao, Y., Chopra, M., Dujmovic-Basuroski, I., Jin, J., Tang, Y., … Markovic-Plese, S. (2015). IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis. J Immunol, 194(11), 5139–5149. https://doi.org/10.4049/jimmunol.1401680
Zhang, Xin, Yazhong Tao, Manisha Chopra, Irena Dujmovic-Basuroski, Jianping Jin, Yunan Tang, Jelena Drulovic, and Silva Markovic-Plese. “IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis.J Immunol 194, no. 11 (June 1, 2015): 5139–49. https://doi.org/10.4049/jimmunol.1401680.
Zhang X, Tao Y, Chopra M, Dujmovic-Basuroski I, Jin J, Tang Y, et al. IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis. J Immunol. 2015 Jun 1;194(11):5139–49.
Zhang, Xin, et al. “IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis.J Immunol, vol. 194, no. 11, June 2015, pp. 5139–49. Pubmed, doi:10.4049/jimmunol.1401680.
Zhang X, Tao Y, Chopra M, Dujmovic-Basuroski I, Jin J, Tang Y, Drulovic J, Markovic-Plese S. IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis. J Immunol. 2015 Jun 1;194(11):5139–5149.

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

June 1, 2015

Volume

194

Issue

11

Start / End Page

5139 / 5149

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Transforming Growth Factor beta
  • Th17 Cells
  • Multiple Sclerosis, Relapsing-Remitting
  • Male
  • Interleukins
  • Interleukin-17
  • Interleukin-11
  • Inflammation
  • Immunology