Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response.

Journal Article (Journal Article;Review)

Statins' recently discovered anti-inflammatory effects place them at the forefront of the new therapies for chronic inflammatory and autoimmune diseases. Our recent study demonstrated that simvastatin exerts an independent immunomodulatory effect on the human monocytes and CD4+ cells. In addition to the statin-mediated effect on the monocyte cytokine production, which regulates Th17 cell differentiation, simvastatin directly inhibits IL-17 production in CD4+ cells, which may collectively inhibit the autoimmune response in multiple sclerosis (MS), a central nervous system (CNS) inflammatory demyelinating disease.

Full Text

Duke Authors

Cited Authors

  • Zhang, X; Markovic-Plese, S

Published Date

  • 2008

Published In

Volume / Issue

  • 41 / 3

Start / End Page

  • 165 - 174

PubMed ID

  • 18484192

International Standard Serial Number (ISSN)

  • 0257-277X

Digital Object Identifier (DOI)

  • 10.1007/s12026-008-8019-z


  • eng

Conference Location

  • United States