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SATB2 protein expression by immunohistochemistry is a sensitive and specific marker of appendiceal and rectosigmoid well differentiated neuroendocrine tumours.

Publication ,  Journal Article
Hoskoppal, D; Epstein, JI; Gown, AM; Arnold Egloff, SA; Gordetsky, JB; Shi, CJ; Giannico, GA
Published in: Histopathology
March 2020

AIMS: Neuroendocrine neoplasms (NNs) range from well to poorly differentiated and indolent to highly aggressive. The site of origin in metastatic NNs has therapeutic and prognostic implications. SATB2 is a transcriptional regulator involved in osteoblastic and neuronal differentiation and is a sensitive and specific marker of colorectal epithelium. This study aimed to evaluate the expression of SATB2 in NNs from various primary sites and its utility as a marker in determining the site of origin of these neoplasms. METHODS AND RESULTS: SATB2 immunohistochemistry was performed on 266 NNs, including lung small cell carcinomas (n = 39) and carcinoids (n = 30), bladder (n = 21) and prostate (n = 31) small cell carcinomas, and gastrointestinal (GI)/pancreatic NNs of various primary sites (n = 145) consisting of well-differentiated neuroendocrine tumours (WDNET)s (n = 124) and poorly differentiated neuroendocrine carcinomas (PDNEC)s (n = 21). SATB2 was expressed in prostatic (10 of 31, 32%) and bladder (eight of 21, 38%) small cell carcinomas, lung carcinoid tumours (one of 30, 3%), and lung small cell carcinomas (eight of 39, 21%). Among primary GI NNs, SATB2 was expressed in 37 of 124 (30%) WDNETs and four of 21 (19%) PDNECs. Of the former, 15 of 15 (100%) rectal/rectosigmoid and 22 of 22 (100%) appendiceal neoplasms expressed SATB2. Using receiver operator characteristic analysis, SATB2 was a sensitive and specific marker for rectal (100.0%, 80.0%) and appendiceal (100.0%, 84.5%) WDNETs, respectively. CONCLUSIONS: In summary, SATB2 is a sensitive and specific marker for rectal/rectosigmoid and appendiceal WDNETs, and may represent a useful diagnostic tool when these sites of origin are considered in the differential diagnosis.

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Published In

Histopathology

DOI

EISSN

1365-2559

Publication Date

March 2020

Volume

76

Issue

4

Start / End Page

550 / 559

Location

England

Related Subject Headings

  • Transcription Factors
  • Retrospective Studies
  • Pathology
  • Neuroendocrine Tumors
  • Matrix Attachment Region Binding Proteins
  • Male
  • Immunohistochemistry
  • Humans
  • Female
  • Colorectal Neoplasms
 

Citation

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Hoskoppal, D., Epstein, J. I., Gown, A. M., Arnold Egloff, S. A., Gordetsky, J. B., Shi, C. J., & Giannico, G. A. (2020). SATB2 protein expression by immunohistochemistry is a sensitive and specific marker of appendiceal and rectosigmoid well differentiated neuroendocrine tumours. Histopathology, 76(4), 550–559. https://doi.org/10.1111/his.14012
Hoskoppal, Deepthi, Jonathan I. Epstein, Allen M. Gown, Shanna A. Arnold Egloff, Jennifer B. Gordetsky, Chanjuan J. Shi, and Giovanna A. Giannico. “SATB2 protein expression by immunohistochemistry is a sensitive and specific marker of appendiceal and rectosigmoid well differentiated neuroendocrine tumours.Histopathology 76, no. 4 (March 2020): 550–59. https://doi.org/10.1111/his.14012.
Hoskoppal D, Epstein JI, Gown AM, Arnold Egloff SA, Gordetsky JB, Shi CJ, et al. SATB2 protein expression by immunohistochemistry is a sensitive and specific marker of appendiceal and rectosigmoid well differentiated neuroendocrine tumours. Histopathology. 2020 Mar;76(4):550–9.
Hoskoppal, Deepthi, et al. “SATB2 protein expression by immunohistochemistry is a sensitive and specific marker of appendiceal and rectosigmoid well differentiated neuroendocrine tumours.Histopathology, vol. 76, no. 4, Mar. 2020, pp. 550–59. Pubmed, doi:10.1111/his.14012.
Hoskoppal D, Epstein JI, Gown AM, Arnold Egloff SA, Gordetsky JB, Shi CJ, Giannico GA. SATB2 protein expression by immunohistochemistry is a sensitive and specific marker of appendiceal and rectosigmoid well differentiated neuroendocrine tumours. Histopathology. 2020 Mar;76(4):550–559.
Journal cover image

Published In

Histopathology

DOI

EISSN

1365-2559

Publication Date

March 2020

Volume

76

Issue

4

Start / End Page

550 / 559

Location

England

Related Subject Headings

  • Transcription Factors
  • Retrospective Studies
  • Pathology
  • Neuroendocrine Tumors
  • Matrix Attachment Region Binding Proteins
  • Male
  • Immunohistochemistry
  • Humans
  • Female
  • Colorectal Neoplasms