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Adenocarcinoma Ex-Goblet Cell: a Retrospective Experience.

Publication ,  Journal Article
Das, S; Shi, C; Du, L; Idrees, K; Berlin, J
Published in: J Gastrointest Cancer
December 2019

PURPOSE: Adenocarcinoma ex-goblet cell carcinoids (AGCCs) are rare appendiceal tumors with mixed neuroendocrine and glandular features. They tend to behave more aggressively than typical carcinoid tumors, affect younger patients, and have a greater predilection for spreading to the peritoneum. Outcomes of AGCC patients treated with chemotherapy, extrapolated from colon cancer regimens, in the adjuvant or metastatic setting have not been explicitly reported. We sought to explore outcomes of AGCC patients with either local disease treated with adjuvant FOLFOX or metastatic disease treated with FOLFOX/FOLFIRI post-cytoreductive debulking (or CRS plus HIPEC in the peritoneal-limited setting). METHODS: We performed a single-institution retrospective analysis of 23 pathologically identified AGCC patients from Vanderbilt University Medical Center treated with chemotherapy in either the adjuvant or metastatic settings. Each patient's tumor was categorized as group B or group C based on the criteria from Tang et al. Median progression-free survival (PFS) or disease-free survival (DFS) (in the curative setting) and overall survival (OS) were determined for each patient and specified patient subgroup. RESULTS AND CONCLUSION: AGCC patients who were treated with FOLFOX chemotherapy in the adjuvant setting or FOLFOX/FOLFIRI in the metastatic setting experienced prolonged PFS, DFS, and OS. Five patients with peritoneal-limited disease treated with CRS plus HIPEC have not yet reached median PFS or OS. While small sample size, patient selection, and retrospective nature limit the generalizability of findings from our analysis, the efficacy signals we observed suggest prospective evaluation with chemotherapy and CRS plus HIPEC is warranted in AGCC patients.

Duke Scholars

Published In

J Gastrointest Cancer

DOI

EISSN

1941-6636

Publication Date

December 2019

Volume

50

Issue

4

Start / End Page

709 / 715

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Progression-Free Survival
  • Peritoneal Neoplasms
  • Organoplatinum Compounds
  • Middle Aged
  • Male
  • Leucovorin
  • Hyperthermia, Induced
  • Humans
  • Goblet Cells
 

Citation

APA
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ICMJE
MLA
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Das, S., Shi, C., Du, L., Idrees, K., & Berlin, J. (2019). Adenocarcinoma Ex-Goblet Cell: a Retrospective Experience. J Gastrointest Cancer, 50(4), 709–715. https://doi.org/10.1007/s12029-018-0131-2
Das, Satya, Chanjuan Shi, Liping Du, Kamran Idrees, and Jordan Berlin. “Adenocarcinoma Ex-Goblet Cell: a Retrospective Experience.J Gastrointest Cancer 50, no. 4 (December 2019): 709–15. https://doi.org/10.1007/s12029-018-0131-2.
Das S, Shi C, Du L, Idrees K, Berlin J. Adenocarcinoma Ex-Goblet Cell: a Retrospective Experience. J Gastrointest Cancer. 2019 Dec;50(4):709–15.
Das, Satya, et al. “Adenocarcinoma Ex-Goblet Cell: a Retrospective Experience.J Gastrointest Cancer, vol. 50, no. 4, Dec. 2019, pp. 709–15. Pubmed, doi:10.1007/s12029-018-0131-2.
Das S, Shi C, Du L, Idrees K, Berlin J. Adenocarcinoma Ex-Goblet Cell: a Retrospective Experience. J Gastrointest Cancer. 2019 Dec;50(4):709–715.
Journal cover image

Published In

J Gastrointest Cancer

DOI

EISSN

1941-6636

Publication Date

December 2019

Volume

50

Issue

4

Start / End Page

709 / 715

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Progression-Free Survival
  • Peritoneal Neoplasms
  • Organoplatinum Compounds
  • Middle Aged
  • Male
  • Leucovorin
  • Hyperthermia, Induced
  • Humans
  • Goblet Cells