Pancreatic Neuroendocrine Tumors.

Journal Article (Journal Article;Review)

Pancreatic neuroendocrine neoplasms include well-differentiated pancreatic neuroendocrine tumors (PanNETs) and neuroendocrine carcinomas (NECs) with well-differentiated PanNETs accounting for most cases. Other pancreatic primaries and metastatic carcinomas from other sites can mimic pancreatic neuroendocrine neoplasms. Immunohistochemical studies can be used to aid in the differential diagnosis. However, no specific markers are available to differentiate PanNETs from NETs of other sites. Although NECs are uniformly deadly, PanNETs have variable prognosis. Morphology alone cannot predict the tumor behavior. Although some pathologic features are associated with an aggressive course, Ki67 is the only prognostic molecular marker routinely used in clinical practice.

Full Text

Duke Authors

Cited Authors

  • Salaria, SN; Shi, C

Published Date

  • December 2016

Published In

Volume / Issue

  • 9 / 4

Start / End Page

  • 595 - 617

PubMed ID

  • 27926362

Electronic International Standard Serial Number (EISSN)

  • 1875-9157

Digital Object Identifier (DOI)

  • 10.1016/j.path.2016.05.006


  • eng

Conference Location

  • United States