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Expression of CD24, a Stem Cell Marker, in Pancreatic and Small Intestinal Neuroendocrine Tumors.

Publication ,  Journal Article
Salaria, S; Means, A; Revetta, F; Idrees, K; Liu, E; Shi, C
Published in: Am J Clin Pathol
October 2015

OBJECTIVES: CD24 has been considered a normal and cancer stem cell marker. Potential intestinal stem cells weakly express CD24. In the pancreas, CD24 is a possible cancer stem cell marker for ductal adenocarcinoma. METHODS: Expression of CD24 in intestinal and pancreatic neuroendocrine tumors (NETs) was examined. Immunohistochemistry was performed on benign duodenum, ileum mucosa, and pancreas, as well as primary duodenal, primary and metastatic ileal, and pancreatic NETs. RESULTS: Scattered CD24-positive cells were noted in the duodenal and ileal crypts, most of which showed a strong subnuclear labeling pattern. Similar expression was observed in 41 (95%) of 43 primary ileal NETs but in only four (15%) of 26 duodenal NETs (P < .01). In addition, metastatic ileal NETs retained CD24 expression. Pancreatic islets did not express CD24, and only rare cells had subnuclear labeling of CD24 in the pancreatic ducts. Unlike ileal NETs, only five (5%) of 92 pancreatic NETs expressed CD24 in the subnuclear compartment (P < .01). All five NETs showed a unique morphology with prominent stromal fibrosis. CONCLUSIONS: CD24 expression was frequent in primary and metastatic midgut NETs but rare in pancreatic and duodenal NETs. Expression of CD24 in ileal NETs may have future diagnostic and therapeutic implications.

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Published In

Am J Clin Pathol

DOI

EISSN

1943-7722

Publication Date

October 2015

Volume

144

Issue

4

Start / End Page

642 / 648

Location

England

Related Subject Headings

  • Pathology
  • Pancreatic Neoplasms
  • Neuroendocrine Tumors
  • Neoplastic Stem Cells
  • Intestinal Neoplasms
  • Immunohistochemistry
  • Humans
  • CD24 Antigen
  • Biomarkers, Tumor
  • 3202 Clinical sciences
 

Citation

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Salaria, S., Means, A., Revetta, F., Idrees, K., Liu, E., & Shi, C. (2015). Expression of CD24, a Stem Cell Marker, in Pancreatic and Small Intestinal Neuroendocrine Tumors. Am J Clin Pathol, 144(4), 642–648. https://doi.org/10.1309/AJCPMZY5P9TWNJJV
Salaria, Safia, Anna Means, Frank Revetta, Kamran Idrees, Eric Liu, and Chanjuan Shi. “Expression of CD24, a Stem Cell Marker, in Pancreatic and Small Intestinal Neuroendocrine Tumors.Am J Clin Pathol 144, no. 4 (October 2015): 642–48. https://doi.org/10.1309/AJCPMZY5P9TWNJJV.
Salaria S, Means A, Revetta F, Idrees K, Liu E, Shi C. Expression of CD24, a Stem Cell Marker, in Pancreatic and Small Intestinal Neuroendocrine Tumors. Am J Clin Pathol. 2015 Oct;144(4):642–8.
Salaria, Safia, et al. “Expression of CD24, a Stem Cell Marker, in Pancreatic and Small Intestinal Neuroendocrine Tumors.Am J Clin Pathol, vol. 144, no. 4, Oct. 2015, pp. 642–48. Pubmed, doi:10.1309/AJCPMZY5P9TWNJJV.
Salaria S, Means A, Revetta F, Idrees K, Liu E, Shi C. Expression of CD24, a Stem Cell Marker, in Pancreatic and Small Intestinal Neuroendocrine Tumors. Am J Clin Pathol. 2015 Oct;144(4):642–648.
Journal cover image

Published In

Am J Clin Pathol

DOI

EISSN

1943-7722

Publication Date

October 2015

Volume

144

Issue

4

Start / End Page

642 / 648

Location

England

Related Subject Headings

  • Pathology
  • Pancreatic Neoplasms
  • Neuroendocrine Tumors
  • Neoplastic Stem Cells
  • Intestinal Neoplasms
  • Immunohistochemistry
  • Humans
  • CD24 Antigen
  • Biomarkers, Tumor
  • 3202 Clinical sciences