Pancreatic neuroendocrine tumors: pathologic and molecular characteristics.

Journal Article (Journal Article)

Pancreatic neuroendocrine neoplasms include mainly well-differentiated neuroendocrine tumors but also rare poorly differentiated neuroendocrine carcinomas. Molecular mechanisms underlying pancreatic neuroendocrine tumorigenesis have recently been elucidated. While alterations in the chromatin remodeling and PI3K/Akt/mTOR pathways are present in most well-differentiated pancreatic neuroendocrine tumors, mutations in TP53 and RB may contribute to the development of pancreatic poorly differentiated neuroendocrine carcinomas. With these discoveries, new molecular targeted therapies have become available and show promise in some patients with pancreatic well-differentiated neuroendocrine tumor.

Full Text

Duke Authors

Cited Authors

  • Shi, C; Klimstra, DS

Published Date

  • November 2014

Published In

Volume / Issue

  • 31 / 6

Start / End Page

  • 498 - 511

PubMed ID

  • 25441311

International Standard Serial Number (ISSN)

  • 0740-2570

Digital Object Identifier (DOI)

  • 10.1053/j.semdp.2014.08.008


  • eng

Conference Location

  • United States