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Should mesenteric tumor deposits be included in staging of well-differentiated small intestine neuroendocrine tumors?

Publication ,  Journal Article
Gonzalez, RS; Liu, EH; Alvarez, JR; Ayers, GD; Washington, MK; Shi, C
Published in: Mod Pathol
September 2014

Well-differentiated small intestine neuroendocrine tumors can give rise to mesenteric tumor deposits, which are not included in the current American Joint Committee on Cancer staging system for small intestine neuroendocrine tumors, and their impact on patient prognosis is unknown. Seventy-two small intestine neuroendocrine tumors resections were identified in our files with slides, reports, and follow-up data available. Cases were assessed for T-category and for the presence of mesenteric tumor deposits, lymph node metastases, lymphovascular invasion, and liver metastases. Mesenteric tumor deposits were defined as discrete mesenteric tumor nodules ≥1 mm with an irregular growth profile. Similar lesions clearly resulting from extranodal extension or direct contiguous spread by the primary lesion were excluded. Forty-three of the 72 cases had mesenteric tumor deposits (60%). The deposits were significantly associated with lymphovascular invasion (P=0.001), pT3 or pT4 disease (P=0.001), nodal metastases (P=0.040), and liver metastases (P<0.001) at the time of surgery. In addition, four of six cases with tumor deposits and no nodal disease had liver disease. Tumor deposits were associated with an increased incidence of disease progression and death due to the disease (P=0.001). Finally, the presence of tumor deposits at the time of surgery was associated with an increase in hazard of progression or death due to disease (hazard ratio: 4.0; 95% confidence interval: 1.3, 12.5; P=0.016). Mesenteric tumor deposits are present in the majority of cases of small intestine neuroendocrine tumors and are indicators of poor prognosis for this disease. Therefore, they may have a place in staging of small intestine neuroendocrine tumors, perhaps as analogous to lymph node disease.

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Published In

Mod Pathol

DOI

EISSN

1530-0285

Publication Date

September 2014

Volume

27

Issue

9

Start / End Page

1288 / 1295

Location

United States

Related Subject Headings

  • Young Adult
  • Peritoneal Neoplasms
  • Pathology
  • Neuroendocrine Tumors
  • Neoplasm Staging
  • Middle Aged
  • Mesentery
  • Male
  • Lymphatic Metastasis
  • Intestine, Small
 

Citation

APA
Chicago
ICMJE
MLA
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Gonzalez, R. S., Liu, E. H., Alvarez, J. R., Ayers, G. D., Washington, M. K., & Shi, C. (2014). Should mesenteric tumor deposits be included in staging of well-differentiated small intestine neuroendocrine tumors? Mod Pathol, 27(9), 1288–1295. https://doi.org/10.1038/modpathol.2013.232
Gonzalez, Raul S., Eric H. Liu, JoAnn R. Alvarez, Gregory D. Ayers, M Kay Washington, and Chanjuan Shi. “Should mesenteric tumor deposits be included in staging of well-differentiated small intestine neuroendocrine tumors?Mod Pathol 27, no. 9 (September 2014): 1288–95. https://doi.org/10.1038/modpathol.2013.232.
Gonzalez RS, Liu EH, Alvarez JR, Ayers GD, Washington MK, Shi C. Should mesenteric tumor deposits be included in staging of well-differentiated small intestine neuroendocrine tumors? Mod Pathol. 2014 Sep;27(9):1288–95.
Gonzalez, Raul S., et al. “Should mesenteric tumor deposits be included in staging of well-differentiated small intestine neuroendocrine tumors?Mod Pathol, vol. 27, no. 9, Sept. 2014, pp. 1288–95. Pubmed, doi:10.1038/modpathol.2013.232.
Gonzalez RS, Liu EH, Alvarez JR, Ayers GD, Washington MK, Shi C. Should mesenteric tumor deposits be included in staging of well-differentiated small intestine neuroendocrine tumors? Mod Pathol. 2014 Sep;27(9):1288–1295.

Published In

Mod Pathol

DOI

EISSN

1530-0285

Publication Date

September 2014

Volume

27

Issue

9

Start / End Page

1288 / 1295

Location

United States

Related Subject Headings

  • Young Adult
  • Peritoneal Neoplasms
  • Pathology
  • Neuroendocrine Tumors
  • Neoplasm Staging
  • Middle Aged
  • Mesentery
  • Male
  • Lymphatic Metastasis
  • Intestine, Small