Molecular characterization of pancreatic neoplasms.

Journal Article (Journal Article;Review)

Molecular analyses of neoplasms of the pancreas, coupled with careful histopathologic examination has helped refine the classification of pancreatic neoplasia. A number of molecularly and histologically distinct subtypes of pancreatic neoplasms have been identified and, importantly, many of these subtypes have important clinical implications. For example, most of the solid-pseudopapillary neoplasms harbor mutations in the beta-catenin gene (CTNNB1), and, as a result, most solid-pseudopapillary neoplasms have an abnormal nuclear pattern of labeling with antibodies to the beta-catenin protein. Clinically, patients with a solid-pseudopapillary neoplasm have a much better prognosis than do patients with ductal adenocarcinoma of the pancreas. Therefore, the immunolabeling of a pancreatic biopsy for the beta-catenin protein can help identify patients with low-risk neoplasms. It is clear that the time is now ripe for a new modern classification of neoplasms of the pancreas; a classification that does not abandon gross and microscopic pathology, but which instead integrates molecular findings with gross, microscopic, and clinical findings.

Full Text

Duke Authors

Cited Authors

  • Shi, C; Daniels, JA; Hruban, RH

Published Date

  • July 2008

Published In

Volume / Issue

  • 15 / 4

Start / End Page

  • 185 - 195

PubMed ID

  • 18580095

Electronic International Standard Serial Number (EISSN)

  • 1533-4031

Digital Object Identifier (DOI)

  • 10.1097/PAP.0b013e31817bf57d


  • eng

Conference Location

  • United States