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Abstract A23: Oncogenic Ras induces inflammatory cytokine production by upregulating squamous cell carcinoma antigen (SerpinB3)

Publication ,  Conference
Catanzaro, J; Sheshadri, N; Pan, J-A; Sun, Y; Shi, C; Li, J; Powers, S; Crawford, H; Zong, W-X
Published in: Molecular Cancer Research
December 1, 2014

Mounting evidence indicates that oncogenic Ras can modulate cell autonomous inflammatory cytokine production, although the underlying mechanism remains unclear. Here we show that squamous cell carcinoma antigen (SCCA), a member of the Serpin family of serine/cysteine protease inhibitors, is transcriptionally up-regulated by oncogenic Ras via MAPK and the ETS family transcription factor PEA3. Increased SCCA expression leads to inhibition of protein turnover, unfolded protein response (UPR), activation of NF-κB, and is essential for Ras-mediated cytokine production and tumor growth. Analysis of human colorectal and pancreatic tumor samples reveals a positive correlation between Ras mutation, enhanced SCCA expression, and IL-6 expression. These results indicate that SCCA is a Ras-responsive factor that plays an essential role in Ras-associated cytokine production and tumorigenesis.Citation Format: Joseph Catanzaro, Namratha Sheshadri, Ji-An Pan, Yu Sun, Chanjuan Shi, Jinyu Li, Scott Powers, Howard Crawford, Wei-Xing Zong. Oncogenic Ras induces inflammatory cytokine production by upregulating squamous cell carcinoma antigen (SerpinB3). [abstract]. In: Proceedings of the AACR Special Conference on RAS Oncogenes: From Biology to Therapy; Feb 24-27, 2014; Lake Buena Vista, FL. Philadelphia (PA): AACR; Mol Cancer Res 2014;12(12 Suppl):Abstract nr A23. doi: 10.1158/1557-3125.RASONC14-A23

Duke Scholars

Published In

Molecular Cancer Research

DOI

EISSN

1557-3125

ISSN

1541-7786

Publication Date

December 1, 2014

Volume

12

Issue

12_Supplement

Start / End Page

A23 / A23

Publisher

American Association for Cancer Research (AACR)

Related Subject Headings

  • Oncology & Carcinogenesis
  • Developmental Biology
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
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Catanzaro, J., Sheshadri, N., Pan, J.-A., Sun, Y., Shi, C., Li, J., … Zong, W.-X. (2014). Abstract A23: Oncogenic Ras induces inflammatory cytokine production by upregulating squamous cell carcinoma antigen (SerpinB3). In Molecular Cancer Research (Vol. 12, pp. A23–A23). American Association for Cancer Research (AACR). https://doi.org/10.1158/1557-3125.rasonc14-a23
Catanzaro, Joseph, Namratha Sheshadri, Ji-An Pan, Yu Sun, Chanjuan Shi, Jinyu Li, Scott Powers, Howard Crawford, and Wei-Xing Zong. “Abstract A23: Oncogenic Ras induces inflammatory cytokine production by upregulating squamous cell carcinoma antigen (SerpinB3).” In Molecular Cancer Research, 12:A23–A23. American Association for Cancer Research (AACR), 2014. https://doi.org/10.1158/1557-3125.rasonc14-a23.
Catanzaro J, Sheshadri N, Pan J-A, Sun Y, Shi C, Li J, et al. Abstract A23: Oncogenic Ras induces inflammatory cytokine production by upregulating squamous cell carcinoma antigen (SerpinB3). In: Molecular Cancer Research. American Association for Cancer Research (AACR); 2014. p. A23–A23.
Catanzaro, Joseph, et al. “Abstract A23: Oncogenic Ras induces inflammatory cytokine production by upregulating squamous cell carcinoma antigen (SerpinB3).” Molecular Cancer Research, vol. 12, no. 12_Supplement, American Association for Cancer Research (AACR), 2014, pp. A23–A23. Crossref, doi:10.1158/1557-3125.rasonc14-a23.
Catanzaro J, Sheshadri N, Pan J-A, Sun Y, Shi C, Li J, Powers S, Crawford H, Zong W-X. Abstract A23: Oncogenic Ras induces inflammatory cytokine production by upregulating squamous cell carcinoma antigen (SerpinB3). Molecular Cancer Research. American Association for Cancer Research (AACR); 2014. p. A23–A23.

Published In

Molecular Cancer Research

DOI

EISSN

1557-3125

ISSN

1541-7786

Publication Date

December 1, 2014

Volume

12

Issue

12_Supplement

Start / End Page

A23 / A23

Publisher

American Association for Cancer Research (AACR)

Related Subject Headings

  • Oncology & Carcinogenesis
  • Developmental Biology
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis