Synchronous primary perianal Paget's disease and rectal adenocarcinoma: report of a hitherto undescribed phenomenon.

Journal Article (Journal Article)

Perianal Paget's disease is rare. It usually represents intraepidermal extension of an invasive carcinoma from an adjacent internal organ, but some cases represent primary intraepithelial cutaneous apocrine adenocarcinomas. Here, we report a unique case, which we interpret as synchronous primary perianal Paget's disease and lower rectal adenocarcinoma. Immunohistochemical stains demonstrated that the Paget's cells were CK7+/ CK20-/GCDFP+, whereas the rectal adenocarcinoma was CK7+(variable)/CK20+/GCDFP-. This discordant immunoprofile supported our impression that the Paget's disease in this patient was of cutaneous apocrine origin rather than a pagetoid extension from the patient's nearby rectal adenocarcinoma-to our knowledge a hitherto undocumented occurrence.

Full Text

Duke Authors

Cited Authors

  • Chanjuan Shi, ; Argani, P

Published Date

  • February 2009

Published In

Volume / Issue

  • 17 / 1

Start / End Page

  • 42 - 45

PubMed ID

  • 18499687

International Standard Serial Number (ISSN)

  • 1066-8969

Digital Object Identifier (DOI)

  • 10.1177/1066896908316069


  • eng

Conference Location

  • United States