Skip to main content
Journal cover image

Mechanisms behind adhesive erythrocytes in sickle‐cell disease

Publication ,  Journal Article
Telen, MJ
Published in: ISBT Science Series
July 2012

Erythrocytes containing primarily hemoglobin S (SS RBCs) are abnormally adherent to a number of ligands, including normal constituents of the extracellular matrix as well as those present on the surfaces of other blood cells and endothelial cells. However, SS RBCs are not really very different from normal (AA) RBCs, except that they are younger. In general, they express the same range of adhesion receptors, and the levels of expression of these receptors, although increased in some cases, are not sufficient to explain the difference between the adhesivity of SS and AA RBCs. However, SS RBCs have activated adhesion receptors, and the signaling pathways responsible for this activation are also upregulated in SS RBCs. In addition, SS RBCs convey different extracellular signals, which are also likely to affect their adhesion to other blood cells and endothelial cells. Together, SS RBCs induce cell–cell interactions mediated by the B‐CAM/LU, ICAM4 (LW), CD44 (In), CD47, α4β1 integrin, and CD36 adhesion molecules on SS RBCs with target ligands on leukocytes and endothelial cells. Other, as yet unidentified cell surface moieties on SS RBCs are probably also responsible for SS RBC interactions with P‐selectin. Interestingly, at least some of these RBC adhesion receptors may also mediate adhesion and adverse physiologic events in the setting of transfusion of stored normal RBCs. Therefore, understanding the mechanisms behind SS RBC adhesion may offer opportunities for improving both therapy of sickle‐cell disease as well as transfusion practices.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

ISBT Science Series

DOI

EISSN

1751-2824

ISSN

1751-2816

Publication Date

July 2012

Volume

7

Issue

1

Start / End Page

197 / 201

Publisher

Wiley

Related Subject Headings

  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Telen, M. J. (2012). Mechanisms behind adhesive erythrocytes in sickle‐cell disease. ISBT Science Series, 7(1), 197–201. https://doi.org/10.1111/j.1751-2824.2012.01547.x
Telen, M. J. “Mechanisms behind adhesive erythrocytes in sickle‐cell disease.” ISBT Science Series 7, no. 1 (July 2012): 197–201. https://doi.org/10.1111/j.1751-2824.2012.01547.x.
Telen MJ. Mechanisms behind adhesive erythrocytes in sickle‐cell disease. ISBT Science Series. 2012 Jul;7(1):197–201.
Telen, M. J. “Mechanisms behind adhesive erythrocytes in sickle‐cell disease.” ISBT Science Series, vol. 7, no. 1, Wiley, July 2012, pp. 197–201. Crossref, doi:10.1111/j.1751-2824.2012.01547.x.
Telen MJ. Mechanisms behind adhesive erythrocytes in sickle‐cell disease. ISBT Science Series. Wiley; 2012 Jul;7(1):197–201.
Journal cover image

Published In

ISBT Science Series

DOI

EISSN

1751-2824

ISSN

1751-2816

Publication Date

July 2012

Volume

7

Issue

1

Start / End Page

197 / 201

Publisher

Wiley

Related Subject Headings

  • 3202 Clinical sciences
  • 1103 Clinical Sciences