Metabolism in the tumor microenvironment: insights from single-cell analysis.

Journal Article (Journal Article)

The metabolism of both cancer and immune cells in the tumor microenvironment (TME) is poorly understood since most studies have focused on analysis in bulk samples and ex vivo cell culture models. Our recent analyses of single-cell RNA sequencing data suggest that the metabolic features of single cells within TME differ greatly from those of the bulk measurements. Here, we discuss some key findings about metabolism in cancer and immune cells and discuss possible relevance to immunotherapy.

Full Text

Duke Authors

Cited Authors

  • Xiao, Z; Locasale, JW; Dai, Z

Published Date

  • 2020

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 1726556 -

PubMed ID

  • 32117592

Pubmed Central ID

  • PMC7028342

International Standard Serial Number (ISSN)

  • 2162-4011

Digital Object Identifier (DOI)

  • 10.1080/2162402X.2020.1726556


  • eng

Conference Location

  • United States