Metabolism in the tumor microenvironment: insights from single-cell analysis.

Journal Article (Journal Article)

The metabolism of both cancer and immune cells in the tumor microenvironment (TME) is poorly understood since most studies have focused on analysis in bulk samples and ex vivo cell culture models. Our recent analyses of single-cell RNA sequencing data suggest that the metabolic features of single cells within TME differ greatly from those of the bulk measurements. Here, we discuss some key findings about metabolism in cancer and immune cells and discuss possible relevance to immunotherapy.

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Duke Authors

Locasale, Jason

Cited Authors

Xiao, Z; Locasale, JW; Dai, Z

Published Date

2020

Published In

Oncoimmunology

Volume / Issue

9 / 1

Start / End Page

1726556 -

PubMed ID

32117592

Pubmed Central ID

PMC7028342

International Standard Serial Number (ISSN)

2162-4011

Digital Object Identifier (DOI)

10.1080/2162402X.2020.1726556

Language

Conference Location

United States

Scholars@Duke