Child Neurology: A young child with an undiagnosed case of dystonia responsive to l-dopa.
Journal Article (Journal Article)
Childhood-onset dystonias are a heterogeneously diverse group. There exists a specific set of dystonias that respond profoundly well to low doses of l-dopa (dopa-responsive dystonia [DRD]). Classical DRD is caused by deficiency of GTP cyclohydrolase 1 or tyrosine hydroxylase, but other conditions can cause dystonias that are partially responsive to dopamine. The idea of a diagnostic therapeutic trial with l-dopa for children who present with dystonia has been around for decades and is frequently advocated for; however, l-dopa trials are not without risk.
Full Text
Duke Authors
Cited Authors
- Trau, SP; Gallentine, WB; Mikati, MA
Published Date
- February 18, 2020
Published In
Volume / Issue
- 94 / 7
Start / End Page
- 326 - 328
PubMed ID
- 32015175
Electronic International Standard Serial Number (EISSN)
- 1526-632X
Digital Object Identifier (DOI)
- 10.1212/WNL.0000000000008963
Language
- eng
Conference Location
- United States