DC-CIK as a widely applicable cancer immunotherapy.
Introduction: Immunotherapy is now a standard treatment for many malignancies. Although immune checkpoint inhibition has demonstrated substantial efficacy by enhancing T cell activation and function in the tumor microenvironment, adoptive transfer of T and NK cell products promises to provide activated cells capable of immediate and direct tumor destruction. A widely applicable, non-MHC dependent, cellular therapy, consisting of in vitro generated dendritic cells (DC) combined with cytokine-induced killer cells (CIK), is highly efficient to produce from individual patients and has demonstrated safety and efficacy alone or with chemotherapy.Areas covered: We summarize the clinical data from studies of DC-CIK and discuss future research directions.Expert opinion: Patients with a wide variety of tumor types who have received DC-CIK therapy may experience clinical responses. This versatile therapy synergizes with other anti-cancer therapies including chemotherapy and immunotherapy.
Duke Scholars
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Related Subject Headings
- Tumor Microenvironment
- Survival Rate
- Neoplasms
- Immunotherapy
- Immunology
- Humans
- Dendritic Cells
- Cytokine-Induced Killer Cells
- Combined Modality Therapy
- 3206 Medical biotechnology
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tumor Microenvironment
- Survival Rate
- Neoplasms
- Immunotherapy
- Immunology
- Humans
- Dendritic Cells
- Cytokine-Induced Killer Cells
- Combined Modality Therapy
- 3206 Medical biotechnology