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Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion.

Publication ,  Journal Article
Cleynen, I; Engchuan, W; Hestand, MS; Heung, T; Holleman, AM; Johnston, HR; Monfeuga, T; McDonald-McGinn, DM; Gur, RE; Morrow, BE; Swillen, A ...
Published in: Mol Psychiatry
August 2021

Schizophrenia occurs in about one in four individuals with 22q11.2 deletion syndrome (22q11.2DS). The aim of this International Brain and Behavior 22q11.2DS Consortium (IBBC) study was to identify genetic factors that contribute to schizophrenia, in addition to the ~20-fold increased risk conveyed by the 22q11.2 deletion. Using whole-genome sequencing data from 519 unrelated individuals with 22q11.2DS, we conducted genome-wide comparisons of common and rare variants between those with schizophrenia and those with no psychotic disorder at age ≥25 years. Available microarray data enabled direct comparison of polygenic risk for schizophrenia between 22q11.2DS and independent population samples with no 22q11.2 deletion, with and without schizophrenia (total n = 35,182). Polygenic risk for schizophrenia within 22q11.2DS was significantly greater for those with schizophrenia (padj = 6.73 × 10-6). Novel reciprocal case-control comparisons between the 22q11.2DS and population-based cohorts showed that polygenic risk score was significantly greater in individuals with psychotic illness, regardless of the presence of the 22q11.2 deletion. Within the 22q11.2DS cohort, results of gene-set analyses showed some support for rare variants affecting synaptic genes. No common or rare variants within the 22q11.2 deletion region were significantly associated with schizophrenia. These findings suggest that in addition to the deletion conferring a greatly increased risk to schizophrenia, the risk is higher when the 22q11.2 deletion and common polygenic risk factors that contribute to schizophrenia in the general population are both present.

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Published In

Mol Psychiatry

DOI

EISSN

1476-5578

Publication Date

August 2021

Volume

26

Issue

8

Start / End Page

4496 / 4510

Location

England

Related Subject Headings

  • Schizophrenia
  • Psychotic Disorders
  • Psychiatry
  • Humans
  • DiGeorge Syndrome
  • Cohort Studies
  • Case-Control Studies
  • Adult
  • 5203 Clinical and health psychology
  • 5202 Biological psychology
 

Citation

APA
Chicago
ICMJE
MLA
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Cleynen, I., Engchuan, W., Hestand, M. S., Heung, T., Holleman, A. M., Johnston, H. R., … Bassett, A. S. (2021). Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion. Mol Psychiatry, 26(8), 4496–4510. https://doi.org/10.1038/s41380-020-0654-3
Cleynen, Isabelle, Worrawat Engchuan, Matthew S. Hestand, Tracy Heung, Aaron M. Holleman, H Richard Johnston, Thomas Monfeuga, et al. “Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion.Mol Psychiatry 26, no. 8 (August 2021): 4496–4510. https://doi.org/10.1038/s41380-020-0654-3.
Cleynen I, Engchuan W, Hestand MS, Heung T, Holleman AM, Johnston HR, et al. Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion. Mol Psychiatry. 2021 Aug;26(8):4496–510.
Cleynen, Isabelle, et al. “Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion.Mol Psychiatry, vol. 26, no. 8, Aug. 2021, pp. 4496–510. Pubmed, doi:10.1038/s41380-020-0654-3.
Cleynen I, Engchuan W, Hestand MS, Heung T, Holleman AM, Johnston HR, Monfeuga T, McDonald-McGinn DM, Gur RE, Morrow BE, Swillen A, Vorstman JAS, Bearden CE, Chow EWC, van den Bree M, Emanuel BS, Vermeesch JR, Warren ST, Owen MJ, Chopra P, Cutler DJ, Duncan R, Kotlar AV, Mulle JG, Voss AJ, Zwick ME, Diacou A, Golden A, Guo T, Lin J-R, Wang T, Zhang Z, Zhao Y, Marshall C, Merico D, Jin A, Lilley B, Salmons HI, Tran O, Holmans P, Pardinas A, Walters JTR, Demaerel W, Boot E, Butcher NJ, Costain GA, Lowther C, Evers R, van Amelsvoort TAMJ, van Duin E, Vingerhoets C, Breckpot J, Devriendt K, Vergaelen E, Vogels A, Crowley TB, McGinn DE, Moss EM, Sharkus RJ, Unolt M, Zackai EH, Calkins ME, Gallagher RS, Gur RC, Tang SX, Fritsch R, Ornstein C, Repetto GM, Breetvelt E, Duijff SN, Fiksinski A, Moss H, Niarchou M, Murphy KC, Prasad SE, Daly EM, Gudbrandsen M, Murphy CM, Murphy DG, Buzzanca A, Fabio FD, Digilio MC, Pontillo M, Marino B, Vicari S, Coleman K, Cubells JF, Ousley OY, Carmel M, Gothelf D, Mekori-Domachevsky E, Michaelovsky E, Weinberger R, Weizman A, Kushan L, Jalbrzikowski M, Armando M, Eliez S, Sandini C, Schneider M, Béna FS, Antshel KM, Fremont W, Kates WR, Belzeaux R, Busa T, Philip N, Campbell LE, McCabe KL, Hooper SR, Schoch K, Shashi V, Simon TJ, Tassone F, Arango C, Fraguas D, García-Miñaúr S, Morey-Canyelles J, Rosell J, Suñer DH, Raventos-Simic J, International 22q11.2DS Brain and Behavior Consortium, Epstein MP, Williams NM, Bassett AS. Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion. Mol Psychiatry. 2021 Aug;26(8):4496–4510.

Published In

Mol Psychiatry

DOI

EISSN

1476-5578

Publication Date

August 2021

Volume

26

Issue

8

Start / End Page

4496 / 4510

Location

England

Related Subject Headings

  • Schizophrenia
  • Psychotic Disorders
  • Psychiatry
  • Humans
  • DiGeorge Syndrome
  • Cohort Studies
  • Case-Control Studies
  • Adult
  • 5203 Clinical and health psychology
  • 5202 Biological psychology