Skip to main content
Journal cover image

Association of cognitive impairment and elderly mortality: differences between two cohorts ascertained 6-years apart in China.

Publication ,  Journal Article
Duan, J; Lv, Y-B; Gao, X; Zhou, J-H; Kraus, VB; Zeng, Y; Su, H; Shi, X-M
Published in: BMC Geriatr
January 28, 2020

BACKGROUND: Cognitive impairment is a major contributor to mortality among the elderly. However, the relationship between cognitive impairment evaluated by educational levels and mortality and the trend between cognitive impairment and mortality with time are unclear. We aim to evaluate the differences in associations of cognitive impairment, taking the stratification by educational levels into account, with all-cause mortality and further explore the relationship of cognitive impairment with mortality in different age and sex groups in two cohorts ascertained 6 years apart in China. METHODS: A total of 13,906 and 13,873 Chinese elderly aged 65 years and older were included in the 2002-2008 and 2008-2014 cohorts from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Mortality data was ascertained from interviews with family members or relatives of participants. Cognitive function, evaluated by the Mini-Mental State Examination (MMSE), were defined by different cut-offs taking educational background into account. Cox models were used to explore the relationship of cognitive impairment with mortality. RESULTS: For the 2002-2008 and 2008-2014 cohorts, 55,277 and 53,267 person-years were followed up, and the mean (SD) age were 86.5 (11.6) and 87.2 (11.3) years, respectively. Compared to normal cognition, cognitive impairment was independently associated with higher mortality risk after controlling for potential confounders, with hazard ratios (HRs) of 1.32 (95% confidence interval [CI], 1.25-1.39) in 2002-2008 cohort and 1.26 (95% CI, 1.19-1.32) in 2008-2014 cohort, stratified by educational levels. The trend of cognitive impairment with all-cause mortality risk decreased from 2002 to 2008 to 2008-2014 cohort, while no significant interaction of cognitive impairment with cohort for all-cause mortality was observed. The associations of cognitive impairment and mortality were decreased with age in the two cohorts. CONCLUSIONS: Cognitive impairment evaluated by different cut-offs were associated with increased risk of mortality, especially among those aged 65-79 years in the two cohorts; this advocates that periodic screening for cognitive impairment among the elderly is warranted.

Duke Scholars

Published In

BMC Geriatr

DOI

EISSN

1471-2318

Publication Date

January 28, 2020

Volume

20

Issue

1

Start / End Page

29

Location

England

Related Subject Headings

  • Time Factors
  • Prospective Studies
  • Mortality
  • Mental Status and Dementia Tests
  • Male
  • Longitudinal Studies
  • Longevity
  • Humans
  • Geriatrics
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Duan, J., Lv, Y.-B., Gao, X., Zhou, J.-H., Kraus, V. B., Zeng, Y., … Shi, X.-M. (2020). Association of cognitive impairment and elderly mortality: differences between two cohorts ascertained 6-years apart in China. BMC Geriatr, 20(1), 29. https://doi.org/10.1186/s12877-020-1424-4
Duan, Jun, Yue-Bin Lv, Xiang Gao, Jin-Hui Zhou, Virginia Byers Kraus, Yi Zeng, Hong Su, and Xiao-Ming Shi. “Association of cognitive impairment and elderly mortality: differences between two cohorts ascertained 6-years apart in China.BMC Geriatr 20, no. 1 (January 28, 2020): 29. https://doi.org/10.1186/s12877-020-1424-4.
Duan J, Lv Y-B, Gao X, Zhou J-H, Kraus VB, Zeng Y, et al. Association of cognitive impairment and elderly mortality: differences between two cohorts ascertained 6-years apart in China. BMC Geriatr. 2020 Jan 28;20(1):29.
Duan, Jun, et al. “Association of cognitive impairment and elderly mortality: differences between two cohorts ascertained 6-years apart in China.BMC Geriatr, vol. 20, no. 1, Jan. 2020, p. 29. Pubmed, doi:10.1186/s12877-020-1424-4.
Duan J, Lv Y-B, Gao X, Zhou J-H, Kraus VB, Zeng Y, Su H, Shi X-M. Association of cognitive impairment and elderly mortality: differences between two cohorts ascertained 6-years apart in China. BMC Geriatr. 2020 Jan 28;20(1):29.
Journal cover image

Published In

BMC Geriatr

DOI

EISSN

1471-2318

Publication Date

January 28, 2020

Volume

20

Issue

1

Start / End Page

29

Location

England

Related Subject Headings

  • Time Factors
  • Prospective Studies
  • Mortality
  • Mental Status and Dementia Tests
  • Male
  • Longitudinal Studies
  • Longevity
  • Humans
  • Geriatrics
  • Follow-Up Studies