Cutaneous metastasis of SMARCA4-deficient thoracic sarcoma: A diagnostic dilemma with therapeutic implications.
Journal Article
SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently recognized entity with undifferentiated rhabdoid morphology and mutations in the switch/sucrose nonfermenting BRG1-associated factors complex. Patients are typically males in their fifth decade with a history of smoking who present with rapidly progressive intrathoracic disease and follow an aggressive clinical course. Metastatic disease is reported in up to 77% of cases; however, to our knowledge, cutaneous metastasis has not been reported nor has it been reported as the initial manifestation of the disease. Recognizing SMARCA4-DTS from other types of epithelioid tumors that involve the skin is clinically relevant, as targeted therapies for SMARC-deficient tumors are currently being investigated and early clinical trial data show therapeutic benefit.
Full Text
Duke Authors
Cited Authors
- Leckey, BD; Selim, MA; Al-Rohil, RN
Published Date
- June 2020
Published In
Volume / Issue
- 47 / 6
Start / End Page
- 561 - 565
PubMed ID
- 31995235
Electronic International Standard Serial Number (EISSN)
- 1600-0560
Digital Object Identifier (DOI)
- 10.1111/cup.13652
Language
- eng
Conference Location
- United States