Skip to main content

Home vs hospital treatment of low-risk venous thromboembolism: a systematic review and meta-analysis.

Publication ,  Journal Article
Khatib, R; Ross, S; Kennedy, SA; Florez, ID; Ortel, TL; Nieuwlaat, R; Neumann, I; Witt, DM; Schulman, S; Manja, V; Beyth, R; Clark, NP ...
Published in: Blood advances
February 2020

Increasing evidence supports the safety and effectiveness of managing low-risk deep vein thrombosis (DVT) or pulmonary embolism (PE) in outpatient settings. We performed a systematic review to assess safety and effectiveness of managing patients with DVT or PE at home compared with the hospital. Medline, Embase, and Cochrane databases were searched up to July 2019 for relevant randomized clinical trials (RCTs), and prospective cohort studies. Two investigators independently screened titles and abstracts of identified citations and extracted data from relevant full-text papers. Risk ratios (RRs) were calculated, and certainty of evidence was assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE). Seven RCTs (1922 patients) were included in meta-analyses on managing patients with DVT. Pooled estimates indicated decreased risk of PE (RR = 0.64; 95% confidence interval [CI], 0.44-0.93) and recurrent DVT (RR = 0.61; 95% CI, 0.42-0.90) for home management, both with moderate certainty of the evidence. Reductions in mortality and major bleeding were not significant, both with low certainty of the evidence. Two RCTs (445 patients) were included in meta-analyses on home management of low-risk patients with PE. Pooled estimates indicated no significant difference in all-cause mortality, recurrent PE, and major bleeding, all with low certainty of the evidence. Results of pooled estimates from 3 prospective cohort studies (234 patients) on home management of PE showed similar results. Our findings indicate that low-risk DVT patients had similar or lower risk of patient-important outcomes with home treatment compared with hospital treatment. In patients with low-risk PE, there was important uncertainty about a difference between home and hospital treatment.

Duke Scholars

Published In

Blood advances

DOI

EISSN

2473-9537

ISSN

2473-9529

Publication Date

February 2020

Volume

4

Issue

3

Start / End Page

500 / 513

Related Subject Headings

  • Venous Thrombosis
  • Venous Thromboembolism
  • Pulmonary Embolism
  • Humans
  • Hospitals
  • Anticoagulants
  • 3201 Cardiovascular medicine and haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Khatib, R., Ross, S., Kennedy, S. A., Florez, I. D., Ortel, T. L., Nieuwlaat, R., … Zhang, Y. (2020). Home vs hospital treatment of low-risk venous thromboembolism: a systematic review and meta-analysis. Blood Advances, 4(3), 500–513. https://doi.org/10.1182/bloodadvances.2019001223
Khatib, Rasha, Stephanie Ross, Sean Alexander Kennedy, Ivan D. Florez, Thomas L. Ortel, Robby Nieuwlaat, Ignacio Neumann, et al. “Home vs hospital treatment of low-risk venous thromboembolism: a systematic review and meta-analysis.Blood Advances 4, no. 3 (February 2020): 500–513. https://doi.org/10.1182/bloodadvances.2019001223.
Khatib R, Ross S, Kennedy SA, Florez ID, Ortel TL, Nieuwlaat R, et al. Home vs hospital treatment of low-risk venous thromboembolism: a systematic review and meta-analysis. Blood advances. 2020 Feb;4(3):500–13.
Khatib, Rasha, et al. “Home vs hospital treatment of low-risk venous thromboembolism: a systematic review and meta-analysis.Blood Advances, vol. 4, no. 3, Feb. 2020, pp. 500–13. Epmc, doi:10.1182/bloodadvances.2019001223.
Khatib R, Ross S, Kennedy SA, Florez ID, Ortel TL, Nieuwlaat R, Neumann I, Witt DM, Schulman S, Manja V, Beyth R, Clark NP, Wiercioch W, Schünemann HJ, Zhang Y. Home vs hospital treatment of low-risk venous thromboembolism: a systematic review and meta-analysis. Blood advances. 2020 Feb;4(3):500–513.

Published In

Blood advances

DOI

EISSN

2473-9537

ISSN

2473-9529

Publication Date

February 2020

Volume

4

Issue

3

Start / End Page

500 / 513

Related Subject Headings

  • Venous Thrombosis
  • Venous Thromboembolism
  • Pulmonary Embolism
  • Humans
  • Hospitals
  • Anticoagulants
  • 3201 Cardiovascular medicine and haematology