Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes.
Journal Article (Journal Article)
OBJECTIVE: To determine the associations between age at first postnatal corticosteroids (PNS) exposure and risk for severe bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). STUDY DESIGN: Cohort study of 951 infants born <27 weeks gestational age at NICHD Neonatal Research Network sites who received PNS between 8 days of life (DOL) and 36 weeks' postmenstrual age was used to produce adjusted odds ratios (aOR). RESULTS: Compared with infants in the reference group (22-28 DOL-lowest rate), aOR for severe BPD was similar for children given PNS between DOL 8 and 49 but higher among infants treated at DOL 50-63 (aOR 1.77, 95% CI 1.03-3.06), and at DOL ≥64 (aOR 3.06, 95% CI 1.44-6.48). The aOR for NDI did not vary significantly by age of PNS exposure. CONCLUSION: For infants at high risk of BPD, initial PNS should be considered prior to 50 DOL for the lowest associated odds of severe BPD.
- Ashley, Patricia Lynn
- Cotten, Charles Michael
- Goldberg, Ronald Norman
- Gustafson, Kathryn E.
- Malcolm, William Ferris
- Harmon, HM; Jensen, EA; Tan, S; Chaudhary, AS; Slaughter, JL; Bell, EF; Wyckoff, MH; Hensman, AM; Sokol, GM; DeMauro, SB; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network,
- April 2020
Volume / Issue
- 40 / 4
Start / End Page
- 616 - 627
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)
- United States