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Relationships between the Nicotine Metabolite Ratio and a Panel of Exposure and Effect Biomarkers: Findings from Two Studies of U.S. Commercial Cigarette Smokers.

Publication ,  Journal Article
Carroll, DM; Murphy, SE; Benowitz, NL; Strasser, AA; Kotlyar, M; Hecht, SS; Carmella, SG; McClernon, FJ; Pacek, LR; Dermody, SS; Vandrey, RG ...
Published in: Cancer Epidemiol Biomarkers Prev
April 2020

BACKGROUND: We examined the nicotine metabolite ratio's (NMR) relationship with smoking intensity, nicotine dependence, and a broad array of biomarkers of exposure and biological effect in commercial cigarette smokers. METHODS: Secondary analysis was conducted on two cross-sectional samples of adult, daily smokers from Wave 1 (2013-2014) of the Population Assessment of Tobacco Use and Health (PATH) Study and baseline data from a 2014-2017 randomized clinical trial. Data were restricted to participants of non-Hispanic, white race. The lowest quartile of NMR (<0.26) in the nationally representative PATH Study was used to distinguish slow from normal/fast nicotine metabolizers. NMR was modeled continuously in secondary analysis. RESULTS: Compared with slow metabolizers, normal/fast metabolizers had greater cigarettes per day and higher levels of total nicotine equivalents, tobacco-specific nitrosamines, volatile organic componds, and polycyclic aromatic hydrocarbons. A novel finding was higher levels of inflammatory biomarkers among normal/fast metabolizers versus slow metabolizers. With NMR modeled as a continuous measure, the associations between NMR and biomarkers of inflammation were not significant. CONCLUSIONS: The results are suggestive that normal/fast nicotine metabolizers may be at increased risk for tobacco-related disease due to being heavier smokers, having higher exposure to numerous toxicants and carcinogens, and having higher levels of inflammation when compared with slow metabolizers. IMPACT: This is the first documentation that NMR is not only associated with smoking exposure but also biomarkers of biological effects that are integral in the development of tobacco-related disease. Results provide support for NMR as a biomarker for understanding a smoker's exposure and potential risk for tobacco-related disease.

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Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

April 2020

Volume

29

Issue

4

Start / End Page

871 / 879

Location

United States

Related Subject Headings

  • United States
  • Tobacco Use Disorder
  • Smokers
  • Severity of Illness Index
  • Self Report
  • Randomized Controlled Trials as Topic
  • Nicotine
  • Middle Aged
  • Male
  • Longitudinal Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Carroll, D. M., Murphy, S. E., Benowitz, N. L., Strasser, A. A., Kotlyar, M., Hecht, S. S., … Hatsukami, D. K. (2020). Relationships between the Nicotine Metabolite Ratio and a Panel of Exposure and Effect Biomarkers: Findings from Two Studies of U.S. Commercial Cigarette Smokers. Cancer Epidemiol Biomarkers Prev, 29(4), 871–879. https://doi.org/10.1158/1055-9965.EPI-19-0644
Carroll, Dana M., Sharon E. Murphy, Neal L. Benowitz, Andrew A. Strasser, Michael Kotlyar, Stephen S. Hecht, Steve G. Carmella, et al. “Relationships between the Nicotine Metabolite Ratio and a Panel of Exposure and Effect Biomarkers: Findings from Two Studies of U.S. Commercial Cigarette Smokers.Cancer Epidemiol Biomarkers Prev 29, no. 4 (April 2020): 871–79. https://doi.org/10.1158/1055-9965.EPI-19-0644.
Carroll DM, Murphy SE, Benowitz NL, Strasser AA, Kotlyar M, Hecht SS, et al. Relationships between the Nicotine Metabolite Ratio and a Panel of Exposure and Effect Biomarkers: Findings from Two Studies of U.S. Commercial Cigarette Smokers. Cancer Epidemiol Biomarkers Prev. 2020 Apr;29(4):871–9.
Carroll, Dana M., et al. “Relationships between the Nicotine Metabolite Ratio and a Panel of Exposure and Effect Biomarkers: Findings from Two Studies of U.S. Commercial Cigarette Smokers.Cancer Epidemiol Biomarkers Prev, vol. 29, no. 4, Apr. 2020, pp. 871–79. Pubmed, doi:10.1158/1055-9965.EPI-19-0644.
Carroll DM, Murphy SE, Benowitz NL, Strasser AA, Kotlyar M, Hecht SS, Carmella SG, McClernon FJ, Pacek LR, Dermody SS, Vandrey RG, Donny EC, Hatsukami DK. Relationships between the Nicotine Metabolite Ratio and a Panel of Exposure and Effect Biomarkers: Findings from Two Studies of U.S. Commercial Cigarette Smokers. Cancer Epidemiol Biomarkers Prev. 2020 Apr;29(4):871–879.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

April 2020

Volume

29

Issue

4

Start / End Page

871 / 879

Location

United States

Related Subject Headings

  • United States
  • Tobacco Use Disorder
  • Smokers
  • Severity of Illness Index
  • Self Report
  • Randomized Controlled Trials as Topic
  • Nicotine
  • Middle Aged
  • Male
  • Longitudinal Studies