Prevalence of a Good Perinatal Outcome With Cryopreserved Compared With Fresh Donor Oocytes.
Journal Article
Objective
To compare the odds of a good perinatal outcome between cryopreserved and fresh donor oocytes.Methods
We used the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System to conduct a retrospective cohort study of women undergoing donor oocyte in vitro fertilization (IVF) from 2012 to 2015. Cycles using cryopreserved embryos, a gestational carrier, or preimplantation genetic testing were excluded. The primary outcome was a good perinatal outcome, defined as a singleton live birth at 37 weeks of gestation or more with birth weight at or within 2,500 g and 4,000 g. Secondary outcomes included live birth, multiple birth, and prematurity. Generalized estimating equation models were used to test the effect of oocyte type on the primary outcome while accounting for covariates and the correlation induced by repeated cycles within a patient.Results
Of the 36,925 cycles included in the analysis, 8,381 (22.7%) used cryopreserved and 28,544 (77.3%) used fresh oocytes. The odds of a good perinatal outcome were marginally but significantly lower with cryopreserved than with fresh oocytes before and after covariate adjustment (22.0% vs 24.1%, unadjusted odds ratio [OR] 0.90, 95% CI 0.85-0.96, adjusted OR 0.88, 95% CI 0.81-0.95). Compared with fresh oocytes, cryopreserved oocytes were associated with lower rates of live birth (39.6% vs 47.7%, OR 0.75, 95% CI 0.72-0.79), multiple birth (22.3% vs 31.2%, OR 0.63, 95% CI 0.58-0.69), and prematurity (27.6% vs 30.6%, OR 0.86, 95% CI 0.79-0.94).Conclusion
This retrospective national study demonstrated that the use of cryopreserved compared with fresh donor oocytes in IVF cycles is associated with marginally lower odds of a good perinatal outcome.Full Text
Duke Authors
Cited Authors
- Eaton, JL; Truong, T; Li, Y-J; Polotsky, AJ
Published Date
- March 2020
Published In
Volume / Issue
- 135 / 3
Start / End Page
- 709 - 716
PubMed ID
- 32028490
Pubmed Central ID
- 32028490
Electronic International Standard Serial Number (EISSN)
- 1873-233X
International Standard Serial Number (ISSN)
- 0029-7844
Digital Object Identifier (DOI)
- 10.1097/aog.0000000000003695
Language
- eng