Helicobacter Pylori-mediated carcinogenesis


Book Section

© 2019 Elsevier Inc. All rights reserved. Helicobacter pylori is the most successful bacterial pathogen worldwide, coevolving with humans for millennia and currently infecting over 50% of the global populous. It is a Gram-negative, spiral-shaped organism that can evade the immune response for the lifetime of its host. The identification of H. pylori as an etiological agent of gastric adenocarcinoma led to its classification as a class I carcinogen. Improved hygiene and targeted eradication with antibiotic therapy have been efficacious in reducing the incidence of gastric cancer, but the opportunity remains to further reduce the burden of H. pylori-associated disease through testing and treatment of high-risk populations.

Full Text

Duke Authors

Cited Authors

  • Varga, MG; Epplein, M

Published Date

  • January 1, 2018

Book Title

  • Encyclopedia of Cancer

Start / End Page

  • 187 - 197

International Standard Book Number 13 (ISBN-13)

  • 9780128124857

Digital Object Identifier (DOI)

  • 10.1016/B978-0-12-801238-3.65172-3

Citation Source

  • Scopus