Impact of a recombinant fowlpox vaccine on the efficacy of adoptive cell therapy with tumor infiltrating lymphocytes in a patient with metastatic melanoma.

Published

Journal Article

A patient with metastatic melanoma who had progressive disease after prior surgical resections, high dose interleukin-2, and anti-cytotoxic T lymphocyte antigen-4 antibody received sequential treatments with autologous tumor infiltrating lymphocytes that recognized the gp100 melanocyte differentiation antigen. Although no clinical response was seen when cells were administered alone, an objective clinical response to therapy was seen with tumor infiltrating lymphocytes administered together with a highly immunogenic fowlpox vaccine expressing a gp100: 209-217 (210M) epitope. Persistence of the transferred antigen-specific lymphocytes in the peripheral blood was observed only after adoptive cell therapy plus administration of vaccine. Cell proliferation in vitro was further stimulated by additional vaccine and interleukin-2. The patient has an ongoing partial response at 10 months after the last treatment.

Full Text

Cited Authors

  • Smith, FO; Klapper, JA; Wunderlich, JR; Rosenberg, SA; Dudley, ME

Published Date

  • October 2009

Published In

Volume / Issue

  • 32 / 8

Start / End Page

  • 870 - 874

PubMed ID

  • 19752747

Pubmed Central ID

  • 19752747

Electronic International Standard Serial Number (EISSN)

  • 1537-4513

Digital Object Identifier (DOI)

  • 10.1097/CJI.0b013e3181b36b69

Language

  • eng

Conference Location

  • United States