Anatomical and clinical implications of vagal modulation of the spleen.

Journal Article (Journal Article;Review)

The vagus nerve coordinates most physiologic functions including the cardiovascular and immune systems. This mechanism has significant clinical implications because electrical stimulation of the vagus nerve can control inflammation and organ injury in infectious and inflammatory disorders. The complex mechanisms that mediate vagal modulation of systemic inflammation are mainly regulated via the spleen. More specifically, vagal stimulation prevents organ injury and systemic inflammation by inhibiting the production of cytokines in the spleen. However, the neuronal regulation of the spleen is controversial suggesting that it can be mediated by either monosynaptic innervation of the splenic parenchyma or secondary neurons from the celiac ganglion depending on the experimental conditions. Recent physiologic and anatomic studies suggest that inflammation is regulated by neuro-immune multi-synaptic interactions between the vagus and the splanchnic nerves to modulate the spleen. Here, we review the current knowledge on these interactions, and discuss their experimental and clinical implications in infectious and inflammatory disorders.

Full Text

Duke Authors

Cited Authors

  • Bassi, GS; Kanashiro, A; Coimbra, NC; Terrando, N; Maixner, W; Ulloa, L

Published Date

  • May 2020

Published In

Volume / Issue

  • 112 /

Start / End Page

  • 363 - 373

PubMed ID

  • 32061636

Pubmed Central ID

  • PMC7211143

Electronic International Standard Serial Number (EISSN)

  • 1873-7528

Digital Object Identifier (DOI)

  • 10.1016/j.neubiorev.2020.02.011


  • eng

Conference Location

  • United States