Brain Metastases in Lung Cancers with Emerging Targetable Fusion Drivers.
The management of non-small cell lung cancer (NSCLC) has transformed with the discovery of therapeutically tractable oncogenic drivers. In addition to activating driver mutations, gene fusions or rearrangements form a unique sub-class, with anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) targeted agents approved as the standard of care in the first-line setting for advanced disease. There are a number of emerging fusion drivers, however, including neurotrophin kinase (NTRK), rearrangement during transfection (RET), and neuregulin 1 (NRG1) for which there are evolving high-impact systemic treatment options. Brain metastases are highly prevalent in NSCLC patients, with molecularly selected populations such as epidermal growth factor receptor (EGFR) mutant and ALK-rearranged tumors particularly brain tropic. Accordingly, there exists a substantial body of research pertaining to the understanding of brain metastases in such populations. Little is known, however, on the molecular mechanisms of brain metastases in those with other targetable fusion drivers in NSCLC. This review encompasses key areas including the biological underpinnings of brain metastases in fusion-driven lung cancers, the intracranial efficacy of novel systemic therapies, and future directions required to optimize the control and prevention of brain metastases.
Duke Scholars
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Related Subject Headings
- Receptor, trkA
- Proto-Oncogene Proteins c-ret
- Proto-Oncogene Proteins
- Protein-Tyrosine Kinases
- Oncogene Proteins, Fusion
- Neuregulin-1
- Neoplasm Metastasis
- Molecular Targeted Therapy
- Lung Neoplasms
- Humans
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Location
Related Subject Headings
- Receptor, trkA
- Proto-Oncogene Proteins c-ret
- Proto-Oncogene Proteins
- Protein-Tyrosine Kinases
- Oncogene Proteins, Fusion
- Neuregulin-1
- Neoplasm Metastasis
- Molecular Targeted Therapy
- Lung Neoplasms
- Humans