PTSD Susceptibility and Challenges: Pathophysiological Consequences of Behavioral Symptoms.


Journal Article

INTRODUCTION: Posttraumatic stress disorder (PTSD) can develop during the aftermath of traumatic events. Although many are impacted by several stressors, nearly 3.6% suffer from PTSD in the United States with higher incidence reported in military service personnel. Any injury to the blood-brain barrier can ignite an array of biological signaling molecules in the immune-privileged brain parenchyma, which can disrupt the synaptic neural network, resulting in altered behavior. MATERIALS AND METHODS: In this preliminary study, we compared 20 PTSD veterans with age-matched healthy veterans to identify plasma levels of brain-specific protein markers using enzyme-linked immunosorbent assay/immunofluorometric sandwich assay for neurotrophic factors and neuropoietic cytokines, and catalytic activity of matrix metalloproteinase (MMP) by zymography. RESULTS: We observed an increased level of glial fibrillary acidic protein, tumor necrosis factor-alpha, interleukin 6, and MMP2 and MMP9 but decreased level of brain-derived neurotrophic factor, nerve growth factor-beta, and negligible difference in astroglial marker S100 calcium-binding protein B compared to controls. CONCLUSION: Identification of neural biomarkers is essential to understand the subclinical symptoms for the diagnosis PTSD, which may not be visible by magnetic resonance imaging (MRI/fMRI) and may take years to clinically manifest.

Full Text

Duke Authors

Cited Authors

  • Brahmajothi, MV; Abou-Donia, MB

Published Date

  • January 7, 2020

Published In

Volume / Issue

  • 185 / Suppl 1

Start / End Page

  • 279 - 285

PubMed ID

  • 32074333

Pubmed Central ID

  • 32074333

Electronic International Standard Serial Number (EISSN)

  • 1930-613X

Digital Object Identifier (DOI)

  • 10.1093/milmed/usz321


  • eng

Conference Location

  • England