Report of the National Heart, Lung, and Blood Institute Working Group on Hypertension: Barriers to Translation.

Journal Article (Journal Article;Review)

The National Heart, Lung, and Blood Institute convened a multidisciplinary working group of hypertension researchers on December 6 to 7, 2018, in Bethesda, MD, to share current scientific knowledge in hypertension and to identify barriers to translation of basic into clinical science/trials and implementation of clinical science into clinical care of patients with hypertension. The goals of the working group were (1) to provide an overview of recent discoveries that may be ready for testing in preclinical and clinical studies; (2) to identify gaps in knowledge that impede translation; (3) to highlight the most promising scientific areas in which to pursue translation; (4) to identify key challenges and barriers for moving basic science discoveries into translation, clinical studies, and trials; and (5) to identify roadblocks for effective dissemination and implementation of basic and clinical science in real-world settings. The working group addressed issues that were responsive to many of the objectives of the National Heart, Lung, and Blood Institute Strategic Vision. The working group identified major barriers and opportunities for translating research to improved control of hypertension. This review summarizes the discussion and recommendations of the working group.

Full Text

Duke Authors

Cited Authors

  • Sigmund, CD; Carey, RM; Appel, LJ; Arnett, DK; Bosworth, HB; Cushman, WC; Galis, ZS; Green Parker, M; Hall, JE; Harrison, DG; McDonough, AA; Nicastro, HL; Oparil, S; Osborn, JW; Raizada, MK; Wright, JD; Oh, YS

Published Date

  • April 2020

Published In

Volume / Issue

  • 75 / 4

Start / End Page

  • 902 - 917

PubMed ID

  • 32063061

Pubmed Central ID

  • PMC7067675

Electronic International Standard Serial Number (EISSN)

  • 1524-4563

Digital Object Identifier (DOI)

  • 10.1161/HYPERTENSIONAHA.119.13887


  • eng

Conference Location

  • United States